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Tbio
GATA5
Transcription factor GATA-5

Protein Summary
Description
Transcription factor required during cardiovascular development (PubMed:23289003). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity (By similarity). Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (PubMed:25543888). The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252997
  • ENSP00000252997
  • ENSG00000130700

Symbol
  • CHTD5
  • GATAS
  • bB379O24.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
protein domain
0.73
cell type or tissue
0.7
biological process
0.68
PubMedID
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.97   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.97   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
76.3
lower urinary tract symptom
2
2
0
1.3
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
76.3
lower urinary tract symptom
0
1.3
76.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 5
VGNC:6110
458389
Macaque
GATA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15802]
Mouse
MGI:109497
14464
Rat
RGD:1561365
499951
Dog
GATA binding protein 5
VGNC:41124
485961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 5
Macaque
GATA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:15802]
Mouse
Rat
Dog
GATA binding protein 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BWX5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (89)
1 – 10 of 89
GATA6
Tbio
Family: TF
Novelty: 0.00267511
Score: 0.955
Data Source: STRINGDB
ZFPM2
Tbio
Family: TF
Novelty: 0.01019523
Score: 0.946
Data Source: STRINGDB
ZFPM1
Tbio
Family: TF
Novelty: 0.01061715
Score: 0.936
Data Source: STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.925
Data Source: STRINGDB
GATA2
Tbio
Family: TF
Novelty: 0.00153967
Score: 0.924
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.924
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.923
Data Source: STRINGDB
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.835
Data Source: STRINGDB
LCT
Tbio
Family: Enzyme
Novelty: 0.0019382
Score: 0.804
Data Source: STRINGDB
HNF1A
Tbio
Family: TF
Novelty: 0.00101291
Score: 0.781
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.97

PubMed score by year
PubTator Score  64.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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