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Tbio
PHF7
PHD finger protein 7

Protein Summary
Description
May play a role in spermatogenesis. Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells. The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327906
  • ENSP00000333024
  • ENSG00000010318
  • ENST00000347025
  • ENSP00000246282
  • ENST00000614886
  • ENSP00000480003

Symbol
  • HSPC045
  • HSPC226
  • NYD-SP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
histone modification site profile
0.89
transcription factor perturbation
0.74
tissue sample
0.66
transcription factor binding site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
4
4
93.4
urate measurement
1
4
4
92.9
high density lipoprotein cholesterol measurement
6
6
8
92.2
waist-hip ratio
3
11
12
91.2
BMI-adjusted waist-hip ratio
1
10
10
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
93.4
urate measurement
4
92.9
high density lipoprotein cholesterol measurement
8
92.2
waist-hip ratio
12
91.2
BMI-adjusted waist-hip ratio
10
90.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 7
VGNC:2505
460427
Macaque
PHD finger protein 7
697103
Mouse
MGI:1919088
71838
Rat
RGD:1308638
364510
Dog
PHD finger protein 7
VGNC:44493
476596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 7
Macaque
PHD finger protein 7
Mouse
Rat
Dog
PHD finger protein 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BWX1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
PPP1R12A
Tbio
Family:  Enzyme
Novelty:  0.0028297
p_int:  0.999966986
p_ni:  0.000033014
Score:  0.269
Data Source:  BioPlex,STRINGDB
MICA
Tbio
Novelty:  0.03965901
p_int:  0.999497338
p_ni:  0.000502662
Score:  0.167
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.993563751
p_ni:  0.006436249
Score:  0.528
Data Source:  BioPlex,STRINGDB
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.968843127
p_ni:  0.031156873
Score:  0.798
Data Source:  BioPlex,STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.80707379
p_ni:  0.19292621
Score:  0.188
Data Source:  BioPlex,STRINGDB
SMRP1
Tdark
Novelty:  0.06822838
Score:  0.593
Data Source:  STRINGDB
TCP11
Tbio
Novelty:  0.03751324
Score:  0.585
Data Source:  STRINGDB
MAGEE2
Tdark
Novelty:  0.67122204
Score:  0.559
Data Source:  STRINGDB
YIF1A
Tdark
Novelty:  0.07180782
Score:  0.551
Data Source:  STRINGDB
SPZ1
Tbio
Family:  TF
Novelty:  0.07156505
Score:  0.549
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.76

PubMed score by year
PubTator Score  5.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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