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Tbio
SCRT1
Transcriptional repressor scratch 1

Protein Summary
Description
Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation. This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000569446
  • ENSP00000455711
  • ENSG00000261678

Symbol
  • SCRT
  • ZNF898
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.73
kinase perturbation
0.66
transcription factor
0.62
biological process
0.6
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2176606
170729
Rat
RGD:1306236
366951
Cow
scratch family transcriptional repressor 1
VGNC:34369
618261
Zebrafish
ZDB-GENE-080219-30
564658
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
scratch family transcriptional repressor 1
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BWW7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (12)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (123)
1 – 10 of 123
SLC6A2
Tclin
Family: Transporter
Novelty: 0.00093735
Score: 0.757
Data Source: STRINGDB
ASCL1
Tbio
Family: TF
Novelty: 0.00274239
Score: 0.711
Data Source: STRINGDB
TMEM249
Tdark
Novelty: 11.31914894
Score: 0.692
Data Source: STRINGDB
KCNC1
Tclin
Family: IC
Novelty: 0.00252943
Score: 0.662
Data Source: STRINGDB
CELF3
Tbio
Novelty: 0.01495441
Score: 0.621
Data Source: STRINGDB
GAD2
Tbio
Family: Enzyme
Novelty: 0.00058427
Score: 0.609
Data Source: STRINGDB
CDK5R2
Tbio
Family: Enzyme
Novelty: 0.16247335
Score: 0.597
Data Source: STRINGDB
SLC6A1
Tclin
Family: Transporter
Novelty: 0.00165116
Score: 0.581
Data Source: STRINGDB
SLC8A2
Tbio
Family: Transporter
Novelty: 0.01423879
Score: 0.581
Data Source: STRINGDB
SLC32A1
Tchem
Family: Transporter
Novelty: 0.00237273
Score: 0.572
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.60

PubMed score by year
PubTator Score  42.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer