Protein Summary
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
- ENST00000273395
- ENSP00000273395
- ENSG00000144857
- ENST00000355385
- ENSP00000347546
- ENST00000495514
- ENSP00000418663
- CDON2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
PubMedID | 0.76 | ||
histone modification site profile | 0.75 | ||
kinase perturbation | 0.66 | ||
cell type or tissue | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.26 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 152 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.26 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 152 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
KLHL24
Novelty: 0.04032749
p_int: 0.986416708
p_ni: 0.013576932
p_wrong: 0.00000636
Score: 0.232
Data Source: BioPlex,STRINGDB
OAF
Novelty: 0.07130797
p_int: 0.981094157
p_ni: 0.018795143
p_wrong: 0.0001107
Score: 0.189
Data Source: BioPlex,STRINGDB
ACOX1
Family: Enzyme
Novelty: 0.00473427
p_int: 0.944812419
p_ni: 0.05518758
p_wrong: 1e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
WDR54
Novelty: 1.19807122
p_int: 0.804417525
p_ni: 0.195580194
p_wrong: 0.000002281
Data Source: BioPlex
Nearest Tclin Targets
Pathways (16)
Reactome (8)
KEGG (2)
PathwayCommons (4)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of SMO | ||||
Reactome | Developmental Biology | ||||
Reactome | GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Reactome | Hedgehog 'on' state | ||||
Reactome | Ligand-receptor interactions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of SMO | ||||
Developmental Biology | ||||
GLI proteins bind promoters of Hh responsive genes to promote transcription | ||||
Hedgehog 'on' state | ||||
Ligand-receptor interactions | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 2 | 2 | 69.1 | |||||
2 | 2 | 0 | 1.1 | 52.7 | |||||
adolescent idiopathic scoliosis | 1 | 1 | 0 | 1.1 | 31.4 | ||||
sleep measurement | 1 | 1 | 1 | 30.2 | |||||
1 | 1 | 0 | 1.2 | 21.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 2 | 69.1 | |||||
0 | 1.1 | 52.7 | |||||
adolescent idiopathic scoliosis | 0 | 1.1 | 31.4 | ||||
sleep measurement | 1 | 30.2 | |||||
0 | 1.2 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | BOC cell adhesion associated, oncogene regulated | 460588 | ||||||
Macaque | BOC cell adhesion associated, oncogene regulated | 709028 | ||||||
Mouse | MGI:2151153 | 117606 | ||||||
Rat | RGD:1304550 | 360715 | ||||||
Dog | BOC cell adhesion associated, oncogene regulated | VGNC:38495 | 487979 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | BOC cell adhesion associated, oncogene regulated | |||||
Macaque | BOC cell adhesion associated, oncogene regulated | |||||
Mouse | ||||||
Rat | ||||||
Dog | BOC cell adhesion associated, oncogene regulated | |||||
Publication Statistics
PubMed Score 5.26
PubMed score by year
PubTator Score 123.87
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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