Tbio BOC Brother of CDO

Protein Summary

Description

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• Q9BWV1
• A6NJ30
• B2RMS8
• D3DN70
• Q6UXJ5
• Q8N2P7
• Q8NF26
• Protein BOC

Gene Name

• BOC

Ensembl ID

• ENST00000273395
• ENSP00000273395
• ENSG00000144857
• ENST00000355385
• ENSP00000347546
• ENST00000495514
• ENSP00000418663

Symbol

• CDON2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
PubMedID	0.76
histone modification site profile	0.75
kinase perturbation	0.66
cell type or tissue	0.54

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	1	1	0	1.1	37
colorectal adenoma	EFO_0005406	1	1	0	1.2	30
colorectal cancer	EFO_0005842	1	1	0	1.2	30
body height	EFO_0004339	1	1	1		16.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	0	1.1	37
colorectal adenoma	EFO_0005406	0	1.2	30
colorectal cancer	EFO_0005842	0	1.2	30
body height	EFO_0004339	1		16.9

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	BOC cell adhesion associated, oncogene regulated		460588
Macaque	BOC cell adhesion associated, oncogene regulated		709028
Mouse	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	MGI:2151153	117606
Rat	BOC cell adhesion associated, oncogene regulated	RGD:1304550	360715
Dog	BOC cell adhesion associated, oncogene regulated	VGNC:38495	487979

Species	Name	OMA	EggNOG	Inparanoid
Chimp	BOC cell adhesion associated, oncogene regulated
Macaque	BOC cell adhesion associated, oncogene regulated
Mouse	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
Rat	BOC cell adhesion associated, oncogene regulated
Dog	BOC cell adhesion associated, oncogene regulated

Protein Structure (3 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BWV1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (16)

Reactome (8)

KEGG (2)

PathwayCommons (4)

WikiPathways (2)

Activation of SMO (R-HSA-5635838)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of SMO	18 targets	R-HSA-5635838
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	GLI proteins bind promoters of Hh responsive genes to promote transcription	7 targets	R-HSA-5635851
Reactome	Hedgehog 'on' state	87 targets	R-HSA-5632684
Reactome	Ligand-receptor interactions	8 targets	R-HSA-5632681

Name	Explore in Pharos	Explore in Source
Activation of SMO	18 targets	R-HSA-5635838
Developmental Biology	1055 targets	R-HSA-1266738
GLI proteins bind promoters of Hh responsive genes to promote transcription	7 targets	R-HSA-5635851
Hedgehog 'on' state	87 targets	R-HSA-5632684
Ligand-receptor interactions	8 targets	R-HSA-5632681

Gene Ontology Terms (9)

Components (4)

Processes (5)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
nucleoplasm	Inferred from Direct Assay (IDA)	HPA
plasma membrane	Traceable Author Statement (TAS)	Reactome
axonal growth cone	Inferred from Electronic Annotation (IEA)	Ensembl
integral component of plasma membrane	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

KLHL24

Tbio

Novelty: 0.04032749

p_int: 0.986416708

p_ni: 0.013576932

p_wrong: 0.00000636

Score: 0.232

Data Source: BioPlex,STRINGDB

OAF

Tbio

Novelty: 0.07130797

p_int: 0.981094157

p_ni: 0.018795143

p_wrong: 0.0001107

Score: 0.189

Data Source: BioPlex,STRINGDB

FBXO2

Tbio

Novelty: 0.01578361

p_int: 0.978513561

p_ni: 0.021486439

Data Source: BioPlex

ACOX1

Tbio

Family: Enzyme

Novelty: 0.00473427

p_int: 0.944812419

p_ni: 0.05518758

p_wrong: 1e-9

Score: 0.189

Data Source: BioPlex,STRINGDB

WDR54

Tdark

Novelty: 1.19807122

p_int: 0.804417525

p_ni: 0.195580194

p_wrong: 0.000002281

Data Source: BioPlex

DHH

Tbio

Novelty: 0.00329784

Score: 0.992

Data Source: STRINGDB

IHH

Tbio

Novelty: 0.00174847

Score: 0.963

Data Source: STRINGDB

SHH

Tchem

Novelty: 0.00028347

Score: 0.956

Data Source: Reactome,STRINGDB

PTCH1

Tbio

Novelty: 0.00077635

Score: 0.95

Data Source: Reactome,STRINGDB

GAS1

Tbio

Novelty: 0.00423304

Score: 0.932

Data Source: STRINGDB

Publication Statistics

PubMed Score  5.26

PubMed score by year

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PubTator Score  123.87

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane

GWAS Trait Find Similar Targets

adolescent idiopathic scoliosis
body height
colorectal adenoma
colorectal cancer

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype
skeleton phenotype