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Tbio
BOC
Brother of CDO

Protein Summary
Description
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273395
  • ENSP00000273395
  • ENSG00000144857
  • ENST00000355385
  • ENSP00000347546
  • ENST00000495514
  • ENSP00000418663

Symbol
  • CDON2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.76
histone modification site profile
0.75
kinase perturbation
0.66
cell type or tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.26   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
2
2
69.1
2
2
0
1.1
52.7
adolescent idiopathic scoliosis
1
1
0
1.1
31.4
sleep measurement
1
1
1
30.2
1
1
0
1.2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
69.1
0
1.1
52.7
adolescent idiopathic scoliosis
0
1.1
31.4
sleep measurement
1
30.2
0
1.2
21.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BOC cell adhesion associated, oncogene regulated
460588
Macaque
BOC cell adhesion associated, oncogene regulated
709028
Mouse
MGI:2151153
117606
Rat
RGD:1304550
360715
Dog
BOC cell adhesion associated, oncogene regulated
VGNC:38495
487979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BOC cell adhesion associated, oncogene regulated
Macaque
BOC cell adhesion associated, oncogene regulated
Mouse
Rat
Dog
BOC cell adhesion associated, oncogene regulated
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BWV1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Activation of SMO (R-HSA-5635838)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of SMO
Reactome
Developmental Biology
Reactome
GLI proteins bind promoters of Hh responsive genes to promote transcription
Reactome
Hedgehog 'on' state
Reactome
Ligand-receptor interactions
Name
Explore in Pharos
Explore in Source
Activation of SMO
Developmental Biology
GLI proteins bind promoters of Hh responsive genes to promote transcription
Hedgehog 'on' state
Ligand-receptor interactions
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
KLHL24
Tbio
Novelty:  0.04032749
p_int:  0.986416708
p_ni:  0.013576932
p_wrong:  0.00000636
Score:  0.232
Data Source:  BioPlex,STRINGDB
OAF
Tbio
Novelty:  0.07130797
p_int:  0.981094157
p_ni:  0.018795143
p_wrong:  0.0001107
Score:  0.189
Data Source:  BioPlex,STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.978513561
p_ni:  0.021486439
Data Source:  BioPlex
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
p_int:  0.944812419
p_ni:  0.05518758
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.804417525
p_ni:  0.195580194
p_wrong:  0.000002281
Data Source:  BioPlex
DHH
Tbio
Novelty:  0.00329784
Score:  0.992
Data Source:  STRINGDB
IHH
Tbio
Novelty:  0.00174847
Score:  0.963
Data Source:  STRINGDB
SHH
Tchem
Novelty:  0.00028347
Score:  0.956
Data Source:  Reactome,STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
Score:  0.95
Data Source:  Reactome,STRINGDB
GAS1
Tbio
Novelty:  0.00423304
Score:  0.932
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.26

PubMed score by year
PubTator Score  123.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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