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Tchem
CDK19
Cyclin-dependent kinase 19

Protein Summary
Description
This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323817
  • ENSP00000317665
  • ENSG00000155111
  • ENST00000368911
  • ENSP00000357907

Symbol
  • CDC2L6
  • CDK11
  • KIAA1028
  • CDK11
  • CDC2L6
  • bA346C16.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
molecular function
0.93
transcription factor binding site profile
0.93
histone modification site profile
0.92
microRNA
0.85


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.41   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.41   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (10)
1 – 10 of 10
AST-487
Rendered image for AST-487
linifanib
Rendered image for linifanib
cortistatin A
Rendered image for cortistatin A
CCT251545
Rendered image for CCT251545
SID103904803
Rendered image for SID103904803
JH-VIII-49
Rendered image for JH-VIII-49
CHEMBL4066819
Rendered image for CHEMBL4066819
CHEMBL4578881
Rendered image for CHEMBL4578881
CHEMBL4167193
Rendered image for CHEMBL4167193
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
30.2
mathematical ability
4
1
4
21.5
sex hormone-binding globulin measurement
2
1
2
12.6
cognitive function measurement
1
1
1
12
testosterone measurement
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
30.2
mathematical ability
4
21.5
sex hormone-binding globulin measurement
2
12.6
cognitive function measurement
1
12
testosterone measurement
1
11.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 19
VGNC:7887
743086
Mouse
MGI:1925584
78334
Rat
RGD:1305435
309804
Dog
cyclin dependent kinase 19
VGNC:39050
612317
Horse
cyclin dependent kinase 19
VGNC:51011
100066791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 19
Mouse
Rat
Dog
cyclin dependent kinase 19
Horse
cyclin dependent kinase 19
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BWU1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Developmental Biology
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (112)
1 – 10 of 112
CCNC
Tbio
Novelty:  0.00585842
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDK8
Tchem
Family:  Kinase
Novelty:  0.00508026
p_int:  1
Score:  0.982
Data Source:  BioPlex,STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
p_int:  0.999999508
p_ni:  4.92e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MED19
Tbio
Family:  Enzyme
Novelty:  0.03926689
p_int:  0.999998907
p_ni:  0.000001093
Score:  0.992
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.99999475
p_ni:  0.00000525
Score:  0.989
Data Source:  BioPlex,STRINGDB
MED18
Tbio
Family:  Enzyme
Novelty:  0.04066825
p_int:  0.999903325
p_ni:  0.000096675
Score:  0.993
Data Source:  BioPlex,STRINGDB
MED7
Tbio
Family:  Enzyme
Novelty:  0.04773947
p_int:  0.998973251
p_ni:  0.001026749
Score:  0.996
Data Source:  BioPlex,STRINGDB
MED13
Tbio
Family:  Enzyme
Novelty:  0.02090708
p_int:  0.998249898
p_ni:  0.001750102
Score:  0.997
Data Source:  BioPlex,STRINGDB
FAM49B
Tbio
Novelty:  0.02928708
p_int:  0.998025246
p_ni:  0.001974754
Data Source:  BioPlex
LZIC
Tdark
Novelty:  0.34151594
p_int:  0.996931526
p_ni:  0.003068473
p_wrong:  1e-9
Score:  0.666
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  34.41

PubMed score by year
PubTator Score  30.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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