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Tbio
CHID1
Chitinase domain-containing protein 1

Protein Summary
Description
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323578
  • ENSP00000325055
  • ENSG00000177830
  • ENST00000429789
  • ENSP00000416034
  • ENST00000436108
  • ENSP00000388156
  • ENST00000449825
  • ENSP00000391255
  • ENST00000454838
  • ENSP00000398722
  • ENST00000528581
  • ENSP00000435503

Symbol
  • GL008
  • SICLP
  • SI-CLP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
cell type or tissue
0.73
tissue sample
0.68
cellular component
0.66
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.01   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.01   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
28.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chitinase domain containing 1
VGNC:11295
740654
Macaque
chitinase domain containing 1
701435
Mouse
MGI:1915288
68038
Rat
RGD:1308955
293628
Dog
chitinase domain containing 1
VGNC:39217
475993
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chitinase domain containing 1
Macaque
chitinase domain containing 1
Mouse
Rat
Dog
chitinase domain containing 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BWS9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (20)
1 – 10 of 20
PSAP
Tbio
Novelty: 0.00395347
Score: 0.9
Data Source: STRINGDB
STAB1
Tbio
Novelty: 0.01303265
Score: 0.867
Data Source: STRINGDB
CHI3L2
Tbio
Family: Enzyme
Novelty: 0.02130544
Score: 0.828
Data Source: STRINGDB
CHIT1
Tbio
Family: Enzyme
Novelty: 0.00113383
Score: 0.793
Data Source: STRINGDB
CHI3L1
Tbio
Family: Enzyme
Novelty: 0.00119387
Score: 0.732
Data Source: STRINGDB
CHIA
Tchem
Family: Enzyme
Novelty: 0.00181726
Score: 0.731
Data Source: STRINGDB
COPE
Tbio
Novelty: 0.02037359
Score: 0.685
Data Source: STRINGDB
OVGP1
Tbio
Family: Enzyme
Novelty: 0.00615902
Score: 0.574
Data Source: STRINGDB
CILP2
Tbio
Novelty: 0.07992715
Score: 0.552
Data Source: STRINGDB
CTBS
Tbio
Family: Enzyme
Novelty: 0.00956005
Score: 0.519
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.01

PubMed score by year
PubTator Score  6.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer