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Tbio
PRR14
Proline-rich protein 14

Protein Summary
Description
Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (PubMed:24209742). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (PubMed:24209742). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha (PubMed:25906157). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferation, possibly via binding to GRB2 (PubMed:27041574). The protein encoded by this gene tethers heterochromatin to the nuclear laminar scaffold by binding heterochromatin protein 1 (HP1) and the nuclear lamina. The tether is broken during mitosis and reforms quickly after mitosis, with the encoded protein first binding HP1 and then attaching to the nuclear lamina. This protein also has been shown to promote MyoD activity and ske ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300835
  • ENSP00000300835
  • ENSG00000156858
  • ENST00000542965
  • ENSP00000441641
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.89
histone modification site profile
0.87
transcription factor
0.69
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.39   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
MAN2B2
Tbio
Family:  Enzyme
Novelty:  0.11499103
p_int:  0.999999844
p_ni:  1.55e-7
p_wrong:  1e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999999805
p_ni:  1.95e-7
Score:  0.803
Data Source:  BioPlex,STRINGDB
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.999999615
p_ni:  3.85e-7
Data Source:  BioPlex
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.99999923
p_ni:  7.43e-7
p_wrong:  2.7e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
PPP2R5A
Tchem
Family:  Enzyme
Novelty:  0.03073487
p_int:  0.999992257
p_ni:  0.000007742
p_wrong:  1e-9
Score:  0.747
Data Source:  BioPlex,STRINGDB
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.999937696
p_ni:  0.000062304
Data Source:  BioPlex
CTDSP2
Tbio
Family:  Enzyme
Novelty:  0.01033594
p_int:  0.99986232
p_ni:  0.0001294
p_wrong:  0.00000828
Score:  0.177
Data Source:  BioPlex,STRINGDB
PPP2R5C
Tbio
Family:  Enzyme
Novelty:  0.03336609
p_int:  0.999853737
p_ni:  0.000146263
Score:  0.747
Data Source:  BioPlex,STRINGDB
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.999069899
p_ni:  0.000120023
p_wrong:  0.000810077
Data Source:  BioPlex
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
p_int:  0.998585476
p_ni:  0.001414524
Score:  0.624
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
67.1
heel bone mineral density
1
1
1
45.2
eosinophil count
1
1
1
42.3
self reported educational attainment
1
1
1
29
1
1
0
1.1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
67.1
heel bone mineral density
1
45.2
eosinophil count
1
42.3
self reported educational attainment
1
29
0
1.1
12.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proline rich 14
VGNC:5896
454049
Macaque
proline rich 14
712594
Mouse
MGI:2384565
233895
Rat
Dog
proline rich 14
VGNC:45038
607432
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proline rich 14
Macaque
proline rich 14
Mouse
Rat
Dog
proline rich 14
Publication Statistics
PubMed Score 8.39
PubMed score by year
PubTator Score 5.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title