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Tbio
SFXN3
Sideroflexin-3

Protein Summary
Description
Potential iron transporter.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393459
  • ENSP00000377103
  • ENSG00000107819

Symbol
  • SFX3
  • SLC56A3
  • BA108L7.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
cell type or tissue
0.74
PubMedID
0.7
transcription factor perturbation
0.68
kinase perturbation
0.66


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
1
3
84.6
serum gamma-glutamyl transferase measurement
1
2
2
58.3
mitochondrial heteroplasmy measurement
1
1
1
53.7
mean corpuscular volume
1
1
1
44.2
refractive error measurement
2
1
1
5.5
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
3
84.6
serum gamma-glutamyl transferase measurement
2
58.3
mitochondrial heteroplasmy measurement
1
53.7
mean corpuscular volume
1
44.2
refractive error measurement
1
5.5
40.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 3
VGNC:5725
450683
Macaque
sideroflexin 3
712607
Mouse
MGI:2137679
94280
Rat
RGD:620716
65042
Dog
sideroflexin 3
VGNC:46089
486848
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 3
Macaque
sideroflexin 3
Mouse
Rat
Dog
sideroflexin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BWM7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated targets of C-MYC transcriptional repression
Name
Explore in Pharos
Explore in Source
Validated targets of C-MYC transcriptional repression
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (64)
1 – 10 of 64
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.999572917
p_ni:  0.000427081
p_wrong:  1e-9
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.999456657
p_ni:  0.000543311
p_wrong:  3.2e-8
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.998854768
p_ni:  0.001145189
p_wrong:  4.3e-8
Data Source:  BioPlex
KLRD1
Tbio
Novelty:  0.00218019
p_int:  0.997852144
p_ni:  0.002146335
p_wrong:  0.000001521
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.997235871
p_ni:  0.002763944
p_wrong:  1.85e-7
Data Source:  BioPlex
KCNE1
Tchem
Family:  IC
Novelty:  0.0015463
p_int:  0.995398958
p_ni:  0.004600726
p_wrong:  3.16e-7
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.992401182
p_ni:  0.007598818
Score:  0.152
Data Source:  BioPlex,STRINGDB
NRG1
Tbio
Novelty:  0.00095246
p_int:  0.990861968
p_ni:  0.008096215
p_wrong:  0.001041818
Data Source:  BioPlex
CLEC4E
Tchem
Novelty:  0.00793367
p_int:  0.988671752
p_ni:  0.008538915
p_wrong:  0.002789333
Score:  0.212
Data Source:  BioPlex,STRINGDB
SYP
Tbio
Novelty:  0.00021543
p_int:  0.987916718
p_ni:  0.006530752
p_wrong:  0.00555253
Score:  0.161
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.82

PubMed score by year
PubTator Score  2.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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