Tdark SF3B5 Splicing factor 3B subunit 5

Protein Summary

Description

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome (PubMed:27720643, PubMed:28781166). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937).

Uniprot Accession IDs

• Q9BWJ5
• B2R568
• Q7RTV1
• SF3b5

Gene Name

• SF3B5

Ensembl ID

• ENST00000367569
• ENSP00000356541
• ENSG00000169976

Symbol

• SF3B10
• Ysf3
• SF3b10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
interacting protein	0.89
transcription factor binding site profile	0.89
disease perturbation	0.87
gene perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.71   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 31   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.71   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0