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Tchem
ACAT2
Acetyl-CoA acetyltransferase, cytosolic

Protein Summary
Description
The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367048
  • ENSP00000356015
  • ENSG00000120437

Symbol
  • ACTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
pathway
0.93
protein domain
0.92
histone modification site profile
0.88
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.48   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.48   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3890942
chemical structure image
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (45)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Protein-Protein Interactions (133)
1 – 10 of 133
MLST8
Tbio
Novelty: 0.00212271
p_int: 0.89766563
p_ni: 0.10233437
Score: 0.359
Data Source: BioPlex,STRINGDB
ACAT1
Tchem
Family: Enzyme
Novelty: 0.01281956
p_int: 0.853883349
p_ni: 0.146116651
Score: 0.947
Data Source: BioPlex,STRINGDB
HADH
Tbio
Family: Enzyme
Novelty: 0.00360431
Score: 0.991
Data Source: STRINGDB
HMGCS1
Tchem
Family: Enzyme
Novelty: 0.01850134
Score: 0.989
Data Source: STRINGDB
HMGCS2
Tbio
Family: Enzyme
Novelty: 0.01524028
Score: 0.98
Data Source: STRINGDB
HADHA
Tbio
Novelty: 0.00234785
Score: 0.973
Data Source: STRINGDB
EHHADH
Tbio
Novelty: 0.00763197
Score: 0.971
Data Source: STRINGDB
OXCT1
Tbio
Family: Enzyme
Novelty: 0.0035774
Score: 0.961
Data Source: STRINGDB
ACADS
Tbio
Family: Enzyme
Novelty: 0.00360385
Score: 0.958
Data Source: STRINGDB
HMGCL
Tbio
Family: Enzyme
Novelty: 0.03613197
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  53.48

PubMed score by year
PubTator Score  67.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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