Tbio ACAT2 Acetyl-CoA acetyltransferase, cytosolic

Protein Summary

Description

The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q9BWD1
• B7Z233
• E1P5B1
• Q16146
• Q5TCL7
• Q8TDM4

Gene Name

• ACAT2

Ensembl ID

• ENST00000367048
• ENSP00000356015
• ENSG00000120437

Symbol

• ACTL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
pathway	0.93
protein domain	0.92
histone modification site profile	0.88
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Acetyl-coa Acetyltransferase, Cytosolic

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Acetyl-coa Acetyltransferase, Cytosolic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.84   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 397   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.84   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0