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Tbio
TARS2
Threonine--tRNA ligase, mitochondrial

Protein Classes
Protein Summary
Description
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. The encoded protein is a mitochondrial aminoacyl-tRNA synthetase. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 4. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369054
  • ENSP00000358050
  • ENSG00000143374
  • ENST00000369064
  • ENSP00000358060

Symbol
  • TARSL1
  • thrRS
  • TARSL1
  • COXPD21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.95
disease perturbation
0.9
molecular function
0.88
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.29   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.29   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
71.9
platelet crit
1
1
1
46.6
low density lipoprotein cholesterol measurement
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
71.9
platelet crit
1
46.6
low density lipoprotein cholesterol measurement
1
8.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
threonyl-tRNA synthetase 2, mitochondrial
VGNC:9902
746922
Macaque
threonyl-tRNA synthetase 2, mitochondrial (putative)
707105
Mouse
MGI:1919057
71807
Rat
RGD:1308283
310672
Dog
threonyl-tRNA synthetase 2, mitochondrial
VGNC:49110
608006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
threonyl-tRNA synthetase 2, mitochondrial
Macaque
threonyl-tRNA synthetase 2, mitochondrial (putative)
Mouse
Rat
Dog
threonyl-tRNA synthetase 2, mitochondrial
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BW92-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Protein-Protein Interactions (118)
1 – 10 of 118
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.936
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.935
Data Source: STRINGDB
AARS
Tbio
Family: Enzyme
Novelty: 0.00203732
Score: 0.925
Data Source: STRINGDB
MARS
Tchem
Family: Enzyme
Novelty: 0.01318702
Score: 0.921
Data Source: STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
Score: 0.912
Data Source: STRINGDB
IARS2
Tbio
Family: Enzyme
Novelty: 0.00854621
Score: 0.908
Data Source: STRINGDB
LARS2
Tbio
Family: Enzyme
Novelty: 0.00543895
Score: 0.901
Data Source: STRINGDB
NARS
Tbio
Family: Enzyme
Novelty: 0.01124207
Score: 0.898
Data Source: STRINGDB
VARS2
Tbio
Family: Enzyme
Novelty: 0.00941946
Score: 0.879
Data Source: STRINGDB
PARS2
Tbio
Family: Enzyme
Novelty: 0.01210892
Score: 0.877
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.29

PubMed score by year
PubTator Score  2.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer