NUDT9
ADP-ribose pyrophosphatase, mitochondrial
Protein Summary
Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000302174
- ENSP00000303575
- ENSG00000170502
- ENST00000473942
- ENSP00000421811
- NUDT10
- NUDT10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
histone modification site profile | 0.85 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.78 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.84 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 228 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.84 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 228 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0