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Tdark
YJU2
YJU2 splicing factor homolog

Protein Summary
Description
Part of the catalytic step I spliceosome, C complex (PubMed:29301961). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262962
  • ENSP00000262962
  • ENSG00000105248

Symbol
  • CCDC94
  • CCDC94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
transcription factor binding site profile
0.87
disease perturbation
0.83
transcription factor
0.66
kinase perturbation
0.6


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.37   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.37   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YJU2 splicing factor homolog
VGNC:3641
737551
Mouse
MGI:1920136
72886
Rat
RGD:1589601
501285
Dog
YJU2 splicing factor homolog
VGNC:38875
611929
Horse
YJU2 splicing factor homolog
VGNC:16191
100062073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YJU2 splicing factor homolog
Mouse
Rat
Dog
YJU2 splicing factor homolog
Horse
YJU2 splicing factor homolog
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BW85-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (126)
1 – 10 of 126
SETMAR
Tbio
Family: Epigenetic
Novelty: 0.02859547
p_int: 1
Score: 0.219
Data Source: BioPlex,STRINGDB
TRIM62
Tbio
Family: Enzyme
Novelty: 0.12565021
p_int: 0.99999989
p_ni: 1.09e-7
p_wrong: 2e-9
Score: 0.207
Data Source: BioPlex,STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
p_int: 0.999999329
p_ni: 6.71e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
BCAS2
Tbio
Novelty: 0.05425016
p_int: 0.999729678
p_ni: 0.000270322
Score: 0.905
Data Source: BioPlex,STRINGDB
GPATCH1
Tdark
Novelty: 0.93318176
p_int: 0.999559973
p_ni: 0.000440026
Score: 0.734
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
p_int: 0.999319296
p_ni: 0.000680704
Score: 0.987
Data Source: BioPlex,STRINGDB
SYF2
Tbio
Novelty: 0.06114903
p_int: 0.999245952
p_ni: 0.000754048
Score: 0.959
Data Source: BioPlex,STRINGDB
TYMP
Tclin
Family: Enzyme
Novelty: 0.0015906
p_int: 0.997996622
p_ni: 0.002003378
Data Source: BioPlex
AQR
Tbio
Novelty: 0.00434312
p_int: 0.996667768
p_ni: 0.003332232
Score: 0.608
Data Source: BioPlex,STRINGDB
NPDC1
Tbio
Novelty: 0.05766647
p_int: 0.996443871
p_ni: 0.003555883
p_wrong: 2.47e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.37

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer