Tdark YJU2 YJU2 splicing factor homolog

Protein Summary

Description

Part of the catalytic step I spliceosome, C complex (PubMed:29301961). May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex (PubMed:22952453).

Uniprot Accession IDs

• Q9BW85
• O75270
• Q9H862
• Q9NW16

Gene Name

• YJU2

Ensembl ID

• ENST00000262962
• ENSP00000262962
• ENSG00000105248

Symbol

• CCDC94
• CCDC94

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
transcription factor binding site profile	0.87
disease perturbation	0.83
transcription factor	0.66
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Yju2 Splicing Factor Homolog

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Coiled-coil Domain-containing Protein 94

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.69   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0