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Tbio
IFT27
Intraflagellar transport protein 27 homolog

Protein Summary
Description
Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity). This gene encodes a GTP-binding protein that is a core component of the intraflagellar transport complex B. Characterization of the similar Chlamydomonas protein indicates a function in cell cycle control. Alternative splicing of this gene results in multiple transcript variants. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340630
  • ENSP00000343593
  • ENSG00000100360
  • ENST00000433985
  • ENSP00000393541

Symbol
  • RABL4
  • RAYL
  • RAYL
  • BBS19
  • RABL4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
histone modification site profile
0.87
transcription factor perturbation
0.74
transcription factor
0.72
cellular component
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
2
3
90.4
eosinophil percentage of leukocytes
2
1
2
64.9
sum of eosinophil and basophil counts
1
1
1
60.2
1
1
0
1.1
46.9
eosinophil percentage of granulocytes
1
1
1
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
90.4
eosinophil percentage of leukocytes
2
64.9
sum of eosinophil and basophil counts
1
60.2
0
1.1
46.9
eosinophil percentage of granulocytes
1
45.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 27
VGNC:5271
458800
Mouse
MGI:1914292
67042
Rat
RGD:1308703
300062
Dog
intraflagellar transport 27
VGNC:41885
474517
Horse
intraflagellar transport 27 [Source:HGNC Symbol;Acc:HGNC:18626]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intraflagellar transport 27
Mouse
Rat
Dog
intraflagellar transport 27
Horse
intraflagellar transport 27 [Source:HGNC Symbol;Acc:HGNC:18626]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BW83-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (92)
1 – 10 of 92
IFT80
Tbio
Novelty:  0.04862973
p_int:  0.999999992
p_ni:  7e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
IFT52
Tbio
Novelty:  0.04183122
p_int:  0.999999921
p_ni:  7.9e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
CLUAP1
Tbio
Novelty:  0.08002286
p_int:  0.999999918
p_ni:  6.4e-8
p_wrong:  1.8e-8
Score:  0.962
Data Source:  BioPlex,STRINGDB
IFT88
Tbio
Novelty:  0.00727114
p_int:  0.999999861
p_ni:  3.6e-8
p_wrong:  1.03e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
TRAF3IP1
Tbio
Novelty:  0.0668178
p_int:  0.999999841
p_ni:  1.27e-7
p_wrong:  3.2e-8
Score:  0.966
Data Source:  BioPlex,STRINGDB
IFT46
Tdark
Novelty:  0.11310911
p_int:  0.999999721
p_ni:  2.79e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
TTC30B
Tbio
Novelty:  0.10944566
p_int:  0.999999037
p_ni:  9.63e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999998903
p_ni:  0.000001093
p_wrong:  5e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
IFT74
Tbio
Novelty:  0.07195266
p_int:  0.999998211
p_ni:  0.000001789
Score:  0.989
Data Source:  BioPlex,STRINGDB
IFT81
Tbio
Novelty:  0.01610195
p_int:  0.999997539
p_ni:  0.000002461
Score:  0.99
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.88

PubMed score by year
PubTator Score  9.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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