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Tbio
DDA1
DET1- and DDB1-associated protein 1

Protein Summary
Description
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359866
  • ENSP00000352928
  • ENSG00000130311
  • ENST00000593466
  • ENSP00000473086
  • ENST00000596582
  • ENSP00000472171

Symbol
  • C19orf58
  • PCIA1
  • PCIA1
  • C19orf58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.84
tissue
0.72
tissue sample
0.71
cell type or tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
DET1
Tbio
Novelty:  0.01138079
p_int:  0.998749529
p_ni:  0.001250471
Score:  0.987
Data Source:  BioPlex,STRINGDB
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.997808831
p_ni:  0.002191169
Data Source:  BioPlex
DTL
Tbio
Novelty:  0.01659105
p_int:  0.968154789
p_ni:  0.031845211
Score:  0.919
Data Source:  BioPlex,STRINGDB
RPL23A
Tbio
Novelty:  0.02951947
p_int:  0.953025357
p_ni:  0.046974643
Data Source:  BioPlex
DCAF11
Tbio
Novelty:  0.08318661
p_int:  0.933418797
p_ni:  0.066581203
Score:  0.953
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.923260017
p_ni:  0.076739983
Score:  0.332
Data Source:  BioPlex,STRINGDB
TRPC4AP
Tbio
Novelty:  0.02170224
p_int:  0.916030231
p_ni:  0.083969769
Score:  0.929
Data Source:  BioPlex,STRINGDB
WSB2
Tbio
Novelty:  0.03939755
p_int:  0.813873546
p_ni:  0.186126454
Score:  0.158
Data Source:  BioPlex,STRINGDB
RFPL4B
Tdark
Novelty:  2.42779597
p_int:  0.766416138
p_ni:  0.233583862
Data Source:  BioPlex
DDB1
Tbio
Novelty:  0.00345896
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
8
95.9
6
4
0
1.2
93.9
testosterone measurement
4
2
4
92.7
2
3
0
1.2
92.6
mitochondrial DNA measurement
2
3
3
90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
8
95.9
0
1.2
93.9
testosterone measurement
4
92.7
0
1.2
92.6
mitochondrial DNA measurement
3
90
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DET1 and DDB1 associated 1
719736
Mouse
MGI:1913748
66498
Rat
RGD:1584153
688813
Dog
DET1 and DDB1 associated 1
VGNC:39826
476675
Horse
DET1 and DDB1 associated 1 [Source:HGNC Symbol;Acc:HGNC:28360]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DET1 and DDB1 associated 1
Mouse
Rat
Dog
DET1 and DDB1 associated 1
Horse
DET1 and DDB1 associated 1 [Source:HGNC Symbol;Acc:HGNC:28360]
Publication Statistics
PubMed Score 14.26
PubMed score by year
PubTator Score 9.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title