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Tbio
ELOVL1
Elongation of very long chain fatty acids protein 1

Protein Summary
Description
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372458
  • ENSP00000361536
  • ENSG00000066322
  • ENST00000413844
  • ENSP00000416024
  • ENST00000621943
  • ENSP00000477602

Symbol
  • SSC1
  • Ssc1
  • CGI-88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.95
transcription factor binding site profile
0.69
histone modification site profile
0.67
transcription factor
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.73   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.73   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
HSD17B12
Tbio
Family:  Enzyme
Novelty:  0.02200219
Score:  0.973
Data Source:  STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
Score:  0.935
Data Source:  STRINGDB
ACSL1
Tbio
Family:  Enzyme
Novelty:  0.00336161
Score:  0.927
Data Source:  STRINGDB
ACSL3
Tbio
Family:  Enzyme
Novelty:  0.01772336
Score:  0.919
Data Source:  STRINGDB
ACSL5
Tchem
Family:  Enzyme
Novelty:  0.00850919
Score:  0.91
Data Source:  STRINGDB
ACSL4
Tbio
Family:  Enzyme
Novelty:  0.0072645
Score:  0.907
Data Source:  STRINGDB
ACSBG2
Tbio
Family:  Enzyme
Novelty:  0.1072938
Score:  0.906
Data Source:  STRINGDB
ACSBG1
Tbio
Family:  Enzyme
Novelty:  0.00381436
Score:  0.904
Data Source:  STRINGDB
CERS2
Tbio
Family:  TF
Novelty:  0.00994797
Score:  0.757
Data Source:  STRINGDB
SCD
Tchem
Family:  Enzyme
Novelty:  0.00063325
Score:  0.668
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Linoleic acid (LA) metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Linoleic acid (LA) metabolism
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
4
4
92.3
platelet crit
2
3
4
88.5
systolic blood pressure
1
1
1
71.9
cognitive function measurement
1
1
1
47.7
asparaginase-induced acute pancreatitis
1
1
0
4.6
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
92.3
platelet crit
4
88.5
systolic blood pressure
1
71.9
cognitive function measurement
1
47.7
asparaginase-induced acute pancreatitis
0
4.6
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELOVL fatty acid elongase 1
VGNC:529
456820
Macaque
ELOVL fatty acid elongase 1
700557
Mouse
MGI:1858959
54325
Rat
RGD:1587151
679532
Dog
ELOVL fatty acid elongase 1
VGNC:40319
100855761
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELOVL fatty acid elongase 1
Macaque
ELOVL fatty acid elongase 1
Mouse
Rat
Dog
ELOVL fatty acid elongase 1
Publication Statistics
PubMed Score 34.73
PubMed score by year
PubTator Score 36.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title