Tchem KIFC1 Kinesin-like protein KIFC1

Protein Summary

Description

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

Uniprot Accession IDs

• Q9BW19
• O60887
• Q14834
• Q4KMP0
• Q5SU09
• Q6GMS7
• Q6P4A5
• Q9UQP7

Gene Name

• KIFC1

Ensembl ID

• ENST00000374523
• ENSP00000363647
• ENSG00000204197
• ENST00000428849
• ENSP00000393963
• ENSG00000237649
• ENST00000448818
• ENSP00000407885
• ENSG00000233450

Symbol

• HSET
• KNSL2
• HSET
• KNSL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
molecular function	0.98
interacting protein	0.92
gene perturbation	0.77
PubMedID	0.76

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kifc1

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kifc1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.06   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.06   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0