Tbio MXD3 Max dimerization protein 3

Protein Summary

Description

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q9BW11
• B4E0J1
• Q53HK1
• Q7Z4Y0
• Q8NDJ7
• Q96ME3
• Max dimerizer 3

Gene Name

• MXD3

Ensembl ID

• ENST00000423571
• ENSP00000389716
• ENSG00000213347
• ENST00000427908
• ENSP00000416921
• ENST00000439742
• ENSP00000401867
• ENST00000513063
• ENSP00000421463

Symbol

• BHLHC13
• MAD3
• MYX
• MAD3
• BHLHC13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
small molecule perturbation	0.77
transcription factor binding site profile	0.76
virus perturbation	0.76
histone modification site profile	0.71

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Max Dimerization Protein 3

DTO Classes

Protein / Transcription Factor / Basic Helix-loop-helix Transcription Factor / Max Dimerization Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.74   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.74   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0