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Tbio
MXD3
Max dimerization protein 3

Protein Summary
Description
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity). This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000423571
  • ENSP00000389716
  • ENSG00000213347
  • ENST00000427908
  • ENSP00000416921
  • ENST00000439742
  • ENSP00000401867
  • ENST00000513063
  • ENSP00000421463

Symbol
  • BHLHC13
  • MAD3
  • MYX
  • MAD3
  • BHLHC13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
small molecule perturbation
0.77
transcription factor binding site profile
0.76
virus perturbation
0.76
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.95   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body weights and measures
1
1
1
69.3
sex hormone-binding globulin measurement
2
1
2
61.2
lymphocyte percentage of leukocytes
2
2
2
56.8
neutrophil percentage of leukocytes
2
2
2
53.2
platelet count
1
1
1
28.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body weights and measures
1
69.3
sex hormone-binding globulin measurement
2
61.2
lymphocyte percentage of leukocytes
2
56.8
neutrophil percentage of leukocytes
2
53.2
platelet count
1
28.3
Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (51)
1 – 10 of 51
MNT
Tbio
Family: TF
Novelty: 0.0088423
p_int: 0.999987197
p_ni: 1.17e-7
p_wrong: 0.000012685
Score: 0.422
Data Source: BioPlex,STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
p_int: 0.99969809
p_ni: 0.00030191
Score: 0.742
Data Source: BioPlex,STRINGDB
SAP30L
Tbio
Family: Enzyme
Novelty: 0.20174722
p_int: 0.99967001
p_ni: 0.000328884
p_wrong: 0.000001106
Score: 0.535
Data Source: BioPlex,STRINGDB
SUDS3
Tbio
Family: Enzyme
Novelty: 0.03837881
p_int: 0.999534269
p_ni: 0.000465731
Score: 0.641
Data Source: BioPlex,STRINGDB
ARID4B
Tbio
Family: TF; Epigenetic
Novelty: 0.04182223
p_int: 0.99949017
p_ni: 0.00050983
Score: 0.219
Data Source: BioPlex,STRINGDB
SAP130
Tdark
Family: Enzyme
Novelty: 1.85084032
p_int: 0.999292828
p_ni: 0.000707157
p_wrong: 1.4e-8
Score: 0.655
Data Source: BioPlex,STRINGDB
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
p_int: 0.998942215
p_ni: 0.001057784
p_wrong: 1e-9
Score: 0.682
Data Source: BioPlex,STRINGDB
BRMS1L
Tbio
Novelty: 0.01578276
p_int: 0.99848845
p_ni: 0.001511549
p_wrong: 1e-9
Score: 0.309
Data Source: BioPlex,STRINGDB
TSPYL2
Tbio
Novelty: 0.03720016
p_int: 0.997450698
p_ni: 0.002549302
Data Source: BioPlex
NUP62CL
Tdark
Novelty: 2.93223607
p_int: 0.994621729
p_ni: 0.000010788
p_wrong: 0.005367483
Score: 0.201
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.95

PubMed score by year
PubTator Score  37.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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