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Tbio
TRMT61B
tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial

Protein Summary
Description
Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306108
  • ENSP00000302801
  • ENSG00000171103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.67
tissue sample
0.57
kinase perturbation
0.54
transcription factor binding site profile
0.54
interacting protein
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.999715169
p_ni:  0.000284831
Score:  0.187
Data Source:  BioPlex,STRINGDB
PPTC7
Tdark
Family:  Enzyme
Novelty:  0.36770849
p_int:  0.998988955
p_ni:  0.001011045
Score:  0.215
Data Source:  BioPlex,STRINGDB
CARS2
Tbio
Family:  Enzyme
Novelty:  0.0105933
p_int:  0.998691883
p_ni:  0.000001959
p_wrong:  0.001306158
Score:  0.755
Data Source:  BioPlex,STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
p_int:  0.995188355
p_ni:  0.004811645
Score:  0.179
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.99514983
p_ni:  0.00485017
Score:  0.302
Data Source:  BioPlex,STRINGDB
ATPAF2
Tbio
Family:  Enzyme
Novelty:  0.04184643
p_int:  0.991843822
p_ni:  0.008052891
p_wrong:  0.000103286
Score:  0.221
Data Source:  BioPlex,STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
p_int:  0.98403412
p_ni:  0.015965871
p_wrong:  9e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.976146266
p_ni:  0.023852081
p_wrong:  0.000001652
Score:  0.218
Data Source:  BioPlex,STRINGDB
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.966796308
p_ni:  0.033203692
Score:  0.173
Data Source:  BioPlex,STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
p_int:  0.964886119
p_ni:  0.035113881
Score:  0.156
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the mitochondrion
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
71.3
body mass index
2
2
2
60.9
bone density
1
1
1
58.4
1
1
0
1.1
33.1
1
1
0
1.1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
71.3
body mass index
2
60.9
bone density
1
58.4
0
1.1
33.1
0
1.1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 61B
VGNC:407
459121
Macaque
tRNA methyltransferase 61B
703419
Horse
tRNA methyltransferase 61B
VGNC:24544
100071028
Opossum
tRNA methyltransferase 61B
100031313
Platypus
tRNA methyltransferase 61B
100078676
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 61B
Macaque
tRNA methyltransferase 61B
Horse
tRNA methyltransferase 61B
Opossum
tRNA methyltransferase 61B
Platypus
tRNA methyltransferase 61B
Publication Statistics
PubMed Score 3.64
PubMed score by year
PubTator Score 4.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title