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Tbio
RIOK2
Serine/threonine-protein kinase RIO2

Protein Summary
Description
Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283109
  • ENSP00000283109
  • ENSG00000058729
  • ENST00000508447
  • ENSP00000420932

Symbol
  • RIO2
  • RIO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
molecular function
0.9
transcription factor binding site profile
0.87
kinase perturbation
0.84
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.72   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.72   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (277)
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.999982392
p_ni:  0.000017607
Score:  0.989
Data Source:  BioPlex,STRINGDB
RPS13
Tbio
Novelty:  0.0019983
p_int:  0.999738679
p_ni:  0.000222687
p_wrong:  0.000038633
Score:  0.996
Data Source:  BioPlex,STRINGDB
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.96186035
p_ni:  0.005157502
p_wrong:  0.032982148
Score:  0.188
Data Source:  BioPlex,STRINGDB
PNO1
Tbio
Novelty:  0.05311566
Score:  0.999
Data Source:  STRINGDB
BYSL
Tbio
Novelty:  0.01919968
Score:  0.999
Data Source:  STRINGDB
LTV1
Tbio
Novelty:  0.04050879
Score:  0.999
Data Source:  STRINGDB
TSR1
Tbio
Novelty:  0.01639069
Score:  0.999
Data Source:  STRINGDB
NOB1
Tbio
Novelty:  0.01209681
Score:  0.999
Data Source:  STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.998
Data Source:  STRINGDB
RPS5
Tbio
Novelty:  0.00513677
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
NanoBRET
image for NanoLuc®-RIOK2
  • Institute:  UNC-CH
  • Authors:  Julie Pickett
  • PI:  Tim Willson
  • Assay ID:  BAO_0010069
  • Endpoint:  fold change
  • Endpoint Detection:  fluorescence intensity
  • Repository:  Synapse
NanoBRET
image for NanoLuc®-fused RIOK2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RIO kinase 2
VGNC:50805
461961
Macaque
RIO kinase 2
700738
Rat
RGD:1311588
308201
Dog
RIO kinase 2
VGNC:53201
479147
Horse
RIO kinase 2
VGNC:49355
100064864
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RIO kinase 2
Macaque
RIO kinase 2
Rat
Dog
RIO kinase 2
Horse
RIO kinase 2
Publication Statistics
PubMed Score 39.72
PubMed score by year
PubTator Score 14.06
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title