Tbio GNL3 Guanine nucleotide-binding protein-like 3

Protein Summary

Description

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q9BVP2
• B2RDC1
• Q5PU80
• Q96SV6
• Q96SV7
• Q9UJY0

Gene Name

• GNL3

Ensembl ID

• ENST00000394799
• ENSP00000378278
• ENSG00000163938
• ENST00000418458
• ENSP00000395772

Symbol

• E2IG3
• NS
• NS
• E2IG3
• NNP47
• C77032

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
disease perturbation	0.99
virus perturbation	0.99
molecular function	0.95
interacting protein	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.09   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 451   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.09   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 451   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0