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Tbio
RUSC1
RUN and SH3 domain-containing protein 1

Protein Summary
Description
Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292254
  • ENSP00000292254
  • ENSG00000160753
  • ENST00000368347
  • ENSP00000357331
  • ENST00000368349
  • ENSP00000357333
  • ENST00000368352
  • ENSP00000357336
  • ENST00000368354
  • ENSP00000357338

Symbol
  • NESCA
  • NESCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
cellular component
0.64
tissue sample
0.62
cell line
0.59
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.6   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (21)
1 – 10 of 21
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
Score: 0.9
Data Source: STRINGDB
RUNDC3A
Tdark
Novelty: 0.23296904
Score: 0.811
Data Source: STRINGDB
ZCWPW1
Tbio
Family: Epigenetic
Novelty: 0.11264543
Score: 0.635
Data Source: STRINGDB
GBA
Tclin
Family: Enzyme
Novelty: 0.00051172
Score: 0.625
Data Source: STRINGDB
PORCN
Tchem
Family: Enzyme
Novelty: 0.00834643
Score: 0.618
Data Source: STRINGDB
RUFY1
Tbio
Novelty: 0.16796947
Score: 0.585
Data Source: STRINGDB
METRN
Tbio
Novelty: 0.03357541
Score: 0.579
Data Source: STRINGDB
SGSM1
Tbio
Novelty: 0.27948733
Score: 0.567
Data Source: STRINGDB
KIF5B
Tbio
Novelty: 0.00515256
Score: 0.511
Data Source: STRINGDB
RUFY3
Tbio
Novelty: 0.1517817
Score: 0.51
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.60

PubMed score by year
PubTator Score  4.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer