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Tbio
GGACT
Gamma-glutamylaminecyclotransferase

Protein Summary
Description
Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl-alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine. The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376250
  • ENSP00000365426
  • ENSG00000134864
  • ENST00000455100
  • ENSP00000410449

Symbol
  • A2LD1
  • A2LD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
tissue sample
0.63
microRNA
0.62
transcription factor
0.57
cell type or tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (15)
COL20A1
Tdark
Novelty:  0.39788946
p_int:  0.999866464
p_ni:  0.00013353
p_wrong:  5e-9
Score:  0.517
Data Source:  BioPlex,STRINGDB
GGCT
Tchem
Family:  Enzyme
Novelty:  0.01154389
Score:  0.905
Data Source:  STRINGDB
TTC3
Tbio
Family:  Enzyme
Novelty:  0.03120223
Score:  0.73
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.711
Data Source:  STRINGDB
CAGE1
Tbio
Novelty:  0.00090205
Score:  0.653
Data Source:  STRINGDB
TUBB4A
Tclin
Novelty:  0.00045092
Score:  0.645
Data Source:  STRINGDB
GGT2
Tbio
Family:  Enzyme
Novelty:  0.00399971
Score:  0.629
Data Source:  STRINGDB
GGTLC3
Tdark
Family:  Enzyme
Novelty:  0.00416359
Score:  0.629
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.627
Data Source:  STRINGDB
MC2R
Tclin
Family:  GPCR
Novelty:  0.00485539
Score:  0.624
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
3
2
1
70
refractive error measurement
2
2
1
6.3
66.6
age at onset
1
1
0
6.3
40.7
Myopia
1
1
0
6.3
40.7
smoking behavior
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
70
refractive error measurement
1
6.3
66.6
age at onset
0
6.3
40.7
Myopia
0
6.3
40.7
smoking behavior
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-glutamylamine cyclotransferase
706006
Mouse
MGI:2385008
223267
Rat
RGD:1304748
290500
Dog
gamma-glutamylamine cyclotransferase
VGNC:41196
485534
Horse
gamma-glutamylamine cyclotransferase
VGNC:18323
100062328
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-glutamylamine cyclotransferase
Mouse
Rat
Dog
gamma-glutamylamine cyclotransferase
Horse
gamma-glutamylamine cyclotransferase
Publication Statistics
PubMed Score 5.21
PubMed score by year
PubTator Score 5.00
PubTator score by year
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Related Publications
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PMID
Year
Title