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Tbio
NUP58
Nucleoporin p58/p45

Protein Summary
Description
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381718
  • ENSP00000371137
  • ENSG00000139496
  • ENST00000381736
  • ENSP00000371155
  • ENST00000463407
  • ENSP00000418555

Symbol
  • KIAA0410
  • NUPL1
  • NUP45
  • NUPL1
  • PRO2463
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 58
VGNC:7298
452497
Macaque
nucleoporin 58
709215
Mouse
MGI:1919094
71844
Rat
RGD:631334
245922
Dog
nucleoporin 58
VGNC:44058
477334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 58
Macaque
nucleoporin 58
Mouse
Rat
Dog
nucleoporin 58
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BVL2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (69)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Protein-Protein Interactions (69)
1 – 10 of 69
NUP54
Tbio
Novelty: 0.08155008
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NUP62CL
Tdark
Novelty: 2.93223607
p_int: 0.999999994
p_ni: 6e-9
Score: 0.85
Data Source: BioPlex,STRINGDB
MIB2
Tbio
Family: Enzyme
Novelty: 0.044378
p_int: 0.999997635
p_ni: 0.000002365
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
EEA1
Tbio
Novelty: 0.00242832
p_int: 0.999968763
p_ni: 0.000031236
Score: 0.166
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999901137
p_ni: 0.000098863
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
FBXO28
Tbio
Novelty: 0.10548865
p_int: 0.999834652
p_ni: 0.000165348
Data Source: BioPlex
OSBPL6
Tbio
Novelty: 0.25692861
p_int: 0.99547364
p_ni: 0.00452636
Data Source: BioPlex
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.994682059
p_ni: 0.005317941
Score: 0.311
Data Source: BioPlex,STRINGDB
WDFY2
Tbio
Novelty: 0.01835759
p_int: 0.990384659
p_ni: 0.009608764
p_wrong: 0.000006577
Score: 0.22
Data Source: BioPlex,STRINGDB
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.981942525
p_ni: 0.018057475
Data Source: BioPlex
Publication Statistics
PubMed Score  10.18

PubMed score by year
PubTator Score  6.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer