Tbio NUP58 Nucleoporin p58/p45

Protein Summary

Description

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BVL2
• A6NI12
• B4DZJ1
• O43160
• Q5JRG2
• Q5JRG5

Gene Name

• NUP58

Ensembl ID

• ENST00000381718
• ENSP00000371137
• ENSG00000139496
• ENST00000381736
• ENSP00000371155
• ENST00000463407
• ENSP00000418555

Symbol

• KIAA0410
• NUPL1
• NUP45
• NUPL1
• PRO2463

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.43   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.43   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0