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Tbio
DUSP23
Dual specificity protein phosphatase 23

Protein Summary
Description
Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368107
  • ENSP00000357087
  • ENSG00000158716
  • ENST00000368108
  • ENSP00000357088
  • ENST00000368109
  • ENSP00000357089

Symbol
  • LDP3
  • VHZ
  • VHZ
  • LDP3
  • MOSP
  • LDP-3
  • DUSP25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
virus perturbation
0.72
transcription factor binding site profile
0.69
protein domain
0.58
transcription factor
0.56


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.03   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.03   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 23
VGNC:524
746364
Macaque
dual specificity phosphatase 23
719474
Mouse
MGI:1915690
68440
Rat
RGD:1309202
360881
Horse
dual specificity phosphatase 23
VGNC:17354
100053524
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 23
Macaque
dual specificity phosphatase 23
Mouse
Rat
Horse
dual specificity phosphatase 23
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BVJ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (74)
1 – 10 of 74
SUGP1
Tbio
Novelty: 0.00434166
p_int: 0.998391354
p_ni: 0.001608646
Score: 0.167
Data Source: BioPlex,STRINGDB
ERICH5
Tdark
Novelty: 5.57504212
p_int: 0.995655044
p_ni: 0.004344955
p_wrong: 1e-9
Data Source: BioPlex
C1orf131
Tdark
Novelty: 10.11904762
p_int: 0.991988768
p_ni: 0.008011231
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
RBM27
Tdark
Novelty: 0.04875536
p_int: 0.988069515
p_ni: 0.011930485
Score: 0.186
Data Source: BioPlex,STRINGDB
DNM1L
Tbio
Novelty: 0.00151314
p_int: 0.939316962
p_ni: 0.050209414
p_wrong: 0.010473624
Score: 0.176
Data Source: BioPlex,STRINGDB
CTNNBL1
Tbio
Novelty: 0.0189038
p_int: 0.936106992
p_ni: 0.042431571
p_wrong: 0.021461437
Score: 0.195
Data Source: BioPlex,STRINGDB
PRRC2A
Tbio
Novelty: 0.01493149
p_int: 0.934585121
p_ni: 0.065411509
p_wrong: 0.00000337
Score: 0.183
Data Source: BioPlex,STRINGDB
AHNAK2
Tbio
Novelty: 0.05663435
p_int: 0.92029128
p_ni: 0.079707015
p_wrong: 0.000001705
Score: 0.177
Data Source: BioPlex,STRINGDB
IK
Tbio
Novelty: 0.01510642
p_int: 0.902498595
p_ni: 0.097501359
p_wrong: 4.6e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
SCYL1
Tbio
Family: Kinase
Novelty: 0.03774351
p_int: 0.895706964
p_ni: 0.102261109
p_wrong: 0.002031927
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  16.03

PubMed score by year
PubTator Score  18.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer