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Tbio
UTP14A
U3 small nucleolar RNA-associated protein 14 homolog A

Protein Summary
Description
May be required for ribosome biogenesis. This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394422
  • ENSP00000377944
  • ENSG00000156697
  • ENST00000425117
  • ENSP00000388669

Symbol
  • SDCCAG16
  • Utp14
  • NYCO16
  • SDCCAG16
  • dJ537K23.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor perturbation
0.84
interacting protein
0.82
drug perturbation
0.71
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.46   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.46   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (316)
UTP14C
Tdark
Novelty:  0.22698737
p_int:  0.99887527
p_ni:  0.00112473
Score:  0.901
Data Source:  BioPlex,STRINGDB
PNO1
Tbio
Novelty:  0.05311566
p_int:  0.997527141
p_ni:  0.002472859
Score:  0.997
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.987463125
p_ni:  0.012536875
Score:  0.167
Data Source:  BioPlex,STRINGDB
DHX37
Tdark
Family:  Enzyme
Novelty:  0.02474351
p_int:  0.975351784
p_ni:  0.024648216
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.895300068
p_ni:  0.104699932
Score:  0.974
Data Source:  BioPlex,STRINGDB
DCAF13
Tbio
Novelty:  0.02796363
Score:  0.999
Data Source:  STRINGDB
NOP58
Tbio
Novelty:  0.02148045
Score:  0.999
Data Source:  STRINGDB
MPHOSPH10
Tbio
Novelty:  0.04846226
Score:  0.999
Data Source:  STRINGDB
FTSJ3
Tbio
Family:  Enzyme
Novelty:  0.01888973
Score:  0.998
Data Source:  STRINGDB
NOP56
Tbio
Novelty:  0.01256937
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
47.7
sex hormone-binding globulin measurement
4
1
4
43.8
mean platelet volume
1
1
1
32.6
hematocrit
1
1
1
30.2
platelet count
1
1
1
11.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
47.7
sex hormone-binding globulin measurement
4
43.8
mean platelet volume
1
32.6
hematocrit
1
30.2
platelet count
1
11.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UTP14A, small subunit processome component
VGNC:2907
473776
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UTP14A, small subunit processome component
Publication Statistics
PubMed Score 19.46
PubMed score by year
PubTator Score 5.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title