Tbio UTP14A U3 small nucleolar RNA-associated protein 14 homolog A

Protein Summary

Description

May be required for ribosome biogenesis. This gene encodes a member of the uridine triphosphate 14 family. As an essential component of a large ribonucleoprotein complex bound to the U3 small nucleolar RNA, the encoded protein is involved in ribosome biogenesis and 18S rRNA synthesis. An autosomal retrotransposed copy of this X-linked gene exists on chromosome 13. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9BVJ6
• A8K7A3
• A8MVQ1
• B4DQ08
• E9PEL7
• Q5JYF1

Gene Name

• UTP14A

Ensembl ID

• ENST00000394422
• ENSP00000377944
• ENSG00000156697
• ENST00000425117
• ENSP00000388669

Symbol

• SDCCAG16
• Utp14
• NYCO16
• SDCCAG16
• dJ537K23.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
transcription factor perturbation	0.84
interacting protein	0.82
drug perturbation	0.71
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / U3 Small Nucleolar Rna-associated Protein 14 Homolog A

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / U3 Small Nucleolar Rna-associated Protein 14 Homolog A

DTO Classes

Protein / Enzyme / Nuclease / U3 Small Nucleolar Rna-associated Protein 14 Homolog A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.69   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.69   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0