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Tdark
NOC4L
Nucleolar complex protein 4 homolog

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nucleolar complex associated 4 homolog
710207
Mouse
MGI:2140843
100608
Rat
RGD:1310661
360828
Dog
nucleolar complex associated 4 homolog
VGNC:43875
486225
Horse
nucleolar complex associated 4 homolog
VGNC:20794
100146920
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nucleolar complex associated 4 homolog
Mouse
Rat
Dog
nucleolar complex associated 4 homolog
Horse
nucleolar complex associated 4 homolog
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BVI4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Protein-Protein Interactions (357)
1 – 10 of 357
BYSL
Tbio
Novelty: 0.01919968
p_int: 0.999988569
p_ni: 0.000011365
p_wrong: 6.6e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
ZNF414
Tdark
Novelty: 1.29024829
p_int: 0.999983568
p_ni: 0.000016432
Data Source: BioPlex
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.999222441
p_ni: 0.000777559
Data Source: BioPlex
SEC31A
Tbio
Novelty: 0.0350228
p_int: 0.996188114
p_ni: 0.003811884
p_wrong: 2e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty: 0.00123818
p_int: 0.996068553
p_ni: 0.003931447
p_wrong: 1e-9
Score: 0.207
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.03836262
p_int: 0.995867732
p_ni: 0.004132268
Score: 0.186
Data Source: BioPlex,STRINGDB
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.993996846
p_ni: 0.006003154
Score: 0.947
Data Source: BioPlex,STRINGDB
ZNF324B
Tdark
Family: TF
Novelty: 1.89922228
p_int: 0.993447536
p_ni: 0.006552464
Score: 0.158
Data Source: BioPlex,STRINGDB
RPS14
Tbio
Novelty: 0.00576737
p_int: 0.968656412
p_ni: 0.031343587
Score: 0.976
Data Source: BioPlex,STRINGDB
STX7
Tbio
Novelty: 0.03109969
p_int: 0.947274522
p_ni: 0.052725321
p_wrong: 1.57e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.12

PubMed score by year
PubTator Score  1.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer