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Tbio
PHF20
PHD finger protein 20

Protein Summary
Description
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374012
  • ENSP00000363124
  • ENSG00000025293

Symbol
  • C20orf104
  • GLEA2
  • HCA58
  • NZF
  • TZP
  • NZF
  • TZP
  • GLEA2
  • HCA58
  • TDRD20A
  • C20orf104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.99
virus perturbation
0.95
kinase perturbation
0.91
molecular function
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.92   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.92   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
KANSL1
Tbio
Novelty:  0.03032662
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
KANSL3
Tbio
Novelty:  0.00150009
p_int:  0.999999556
p_ni:  4.43e-7
p_wrong:  2e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
KANSL2
Tbio
Novelty:  0.08741608
p_int:  0.999995453
p_ni:  0.000004546
Score:  0.994
Data Source:  BioPlex,STRINGDB
KAT8
Tchem
Family:  Epigenetic
Novelty:  0.00861497
p_int:  0.999988339
p_ni:  0.00001166
Score:  0.964
Data Source:  BioPlex,STRINGDB
MCRS1
Tbio
Novelty:  0.03404119
p_int:  0.999952274
p_ni:  0.000047726
Score:  0.989
Data Source:  BioPlex,STRINGDB
PTPN14
Tbio
Family:  Enzyme
Novelty:  0.01333024
p_int:  0.999905125
p_ni:  0.000094875
Score:  0.218
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.973
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.972
Data Source:  Reactome,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.946
Data Source:  Reactome,STRINGDB
RBBP5
Tbio
Novelty:  0.02221059
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
G1/S DNA Damage Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Chromatin modifying enzymes
Chromatin organization
G1/S DNA Damage Checkpoints
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
4
7
98.5
BMI-adjusted hip circumference
3
7
7
88.1
body height
1
1
1
84.5
mean platelet volume
2
2
2
77.6
BMI-adjusted waist circumference
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
7
98.5
BMI-adjusted hip circumference
7
88.1
body height
1
84.5
mean platelet volume
2
77.6
BMI-adjusted waist circumference
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 20
VGNC:6233
469928
Macaque
PHD finger protein 20
711122
Mouse
MGI:2444148
228829
Rat
RGD:1305020
311575
Dog
PHD finger protein 20
VGNC:44485
477217
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PHD finger protein 20
Macaque
PHD finger protein 20
Mouse
Rat
Dog
PHD finger protein 20
Publication Statistics
PubMed Score 52.92
PubMed score by year
PubTator Score 32.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title