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Tbio
PTDSS2
Phosphatidylserine synthase 2

Protein Summary
Description
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine. The protein encoded by this gene catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine, a structural membrane phospholipid that functions in cell signaling, blood coagulation, and apoptosis. The encoded enzyme also has a high affinity for docosahexaenoic acid (DHA) and can use it to make DHA-containing phosphatidylserine. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308020
  • ENSP00000308258
  • ENSG00000174915

Symbol
  • PSS2
  • PSS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
ligand (protein) perturbation
0.83
disease perturbation
0.79
kinase perturbation
0.76
small molecule perturbation
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.802955561
p_ni:  0.197044439
Score:  0.224
Data Source:  BioPlex,STRINGDB
PISD
Tbio
Family:  Enzyme
Novelty:  0.00966227
Score:  0.96
Data Source:  STRINGDB
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
Score:  0.959
Data Source:  STRINGDB
PEMT
Tbio
Family:  Enzyme
Novelty:  0.00786252
Score:  0.948
Data Source:  STRINGDB
SELENOI
Tbio
Family:  Enzyme
Novelty:  0.00809865
Score:  0.934
Data Source:  STRINGDB
LPCAT4
Tdark
Family:  Enzyme
Novelty:  0.246654
Score:  0.924
Data Source:  STRINGDB
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
Score:  0.922
Data Source:  STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
Score:  0.92
Data Source:  STRINGDB
PTDSS1
Tbio
Family:  Enzyme
Novelty:  0.01932442
Score:  0.919
Data Source:  STRINGDB
MBOAT1
Tdark
Family:  Enzyme
Novelty:  0.05745641
Score:  0.915
Data Source:  STRINGDB
Pathways (10)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PS
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PS
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
64.4
3
2
0
1.2
54.2
apolipoprotein A 1 measurement
1
1
1
28.1
triglyceride measurement
1
1
1
24.5
lymphocyte count
1
1
1
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
64.4
0
1.2
54.2
apolipoprotein A 1 measurement
1
28.1
triglyceride measurement
1
24.5
lymphocyte count
1
13.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatidylserine synthase 2
698582
Mouse
MGI:1351664
27388
Rat
RGD:1307914
293620
Dog
phosphatidylserine synthase 2
VGNC:45137
483401
Horse
phosphatidylserine synthase 2
VGNC:21983
100054404
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatidylserine synthase 2
Mouse
Rat
Dog
phosphatidylserine synthase 2
Horse
phosphatidylserine synthase 2
Publication Statistics
PubMed Score 11.62
PubMed score by year
PubTator Score 22.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title