EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.87 | ||
histone modification site profile | 0.83 | ||
pathway | 0.8 | ||
transcription factor binding site profile | 0.67 | ||
cellular component | 0.61 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Calnexin/calreticulin cycle | ||||
Reactome | ER Quality Control Compartment (ERQC) | ||||
Reactome | Metabolism of proteins | ||||
Reactome | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Calnexin/calreticulin cycle | ||||
ER Quality Control Compartment (ERQC) | ||||
Metabolism of proteins | ||||
N-glycan trimming in the ER and Calnexin/Calreticulin cycle | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | ParkinsonsUK-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 6 | 12 | 99.1 | |||||
4 | 5 | 2 | 1.1 | 94.7 | |||||
factor VII measurement | 1 | 2 | 2 | 93.6 | |||||
protein C measurement | 2 | 2 | 2 | 91.4 | |||||
glomerular filtration rate | 2 | 3 | 3 | 89.7 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
appendicular lean mass | 12 | 99.1 | |||||
2 | 1.1 | 94.7 | |||||
factor VII measurement | 2 | 93.6 | |||||
protein C measurement | 2 | 91.4 | |||||
glomerular filtration rate | 3 | 89.7 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ER degradation enhancing alpha-mannosidase like protein 2 | VGNC:9844 | 458197 | |||||
Macaque | ER degradation enhancing alpha-mannosidase like protein 2 | 706150 | ||||||
Mouse | MGI:1915540 | 108687 | ||||||
Rat | RGD:1303074 | 296304 | ||||||
Dog | ER degradation enhancing alpha-mannosidase like protein 2 | VGNC:40195 | 477209 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ER degradation enhancing alpha-mannosidase like protein 2 | |||||
Macaque | ER degradation enhancing alpha-mannosidase like protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ER degradation enhancing alpha-mannosidase like protein 2 | |||||
PMID | Year | Title |
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