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Tdark
SNRNP25
U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Protein Summary
Description
Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383018
  • ENSP00000372482
  • ENSG00000161981

Symbol
  • C16orf33
  • C16orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
virus perturbation
0.79
disease perturbation
0.74
transcription factor perturbation
0.74
kinase perturbation
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.1   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U11/U12 subunit 25
VGNC:9106
467847
Mouse
MGI:1925622
78372
Rat
RGD:1310922
287170
Dog
small nuclear ribonucleoprotein U11/U12 subunit 25
VGNC:46605
612990
Horse
small nuclear ribonucleoprotein U11/U12 subunit 25
VGNC:51245
100066312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small nuclear ribonucleoprotein U11/U12 subunit 25
Mouse
Rat
Dog
small nuclear ribonucleoprotein U11/U12 subunit 25
Horse
small nuclear ribonucleoprotein U11/U12 subunit 25
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BV90-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HGNC
Protein-Protein Interactions (96)
1 – 10 of 96
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.02989472
p_int: 0.998979105
p_ni: 4.68e-7
p_wrong: 0.001020427
Score: 0.732
Data Source: BioPlex,STRINGDB
SNRNP48
Tbio
Novelty: 0.16395917
Score: 0.956
Data Source: STRINGDB
ZMAT5
Tdark
Novelty: 0.97115324
Score: 0.951
Data Source: STRINGDB
POLR2F
Tbio
Family: Enzyme
Novelty: 0.03787683
Score: 0.928
Data Source: STRINGDB
POLR3K
Tbio
Family: Enzyme
Novelty: 0.07105011
Score: 0.927
Data Source: STRINGDB
SF3B5
Tdark
Novelty: 0.26636354
Score: 0.923
Data Source: STRINGDB
POLR2I
Tbio
Family: Enzyme
Novelty: 0.03100605
Score: 0.921
Data Source: STRINGDB
POLR2L
Tbio
Family: Enzyme
Novelty: 0.03847579
Score: 0.92
Data Source: STRINGDB
POLR2E
Tbio
Family: Enzyme
Novelty: 0.01817288
Score: 0.919
Data Source: STRINGDB
SNRPD2
Tbio
Novelty: 0.02519503
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.10

PubMed score by year
PubTator Score  0.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer