Tdark SNRNP25 U11/U12 small nuclear ribonucleoprotein 25 kDa protein

Protein Summary

Description

Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q9BV90
• Q1W6H3
• Q6IEF8
• Q9H5W4
• U11/U12 snRNP 25 kDa protein

Gene Name

• SNRNP25

Ensembl ID

• ENST00000383018
• ENSP00000372482
• ENSG00000161981

Symbol

• C16orf33
• C16orf33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
virus perturbation	0.79
disease perturbation	0.74
transcription factor perturbation	0.74
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.44   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.44   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0