You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NTMT1
N-terminal Xaa-Pro-Lys N-methyltransferase 1

Protein Summary
Description
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372480
  • ENSP00000361558
  • ENSG00000148335
  • ENST00000372481
  • ENSP00000361559
  • ENST00000372483
  • ENSP00000361561
  • ENST00000372486
  • ENSP00000361564
  • ENST00000611055
  • ENSP00000483489
  • ENST00000613644
  • ENSP00000478521

Symbol
  • C9orf32
  • METTL11A
  • NRMT
  • NRMT1
  • NRMT
  • NRMT1
  • NTM1A
  • AD-003
  • HOMT1A
  • C9orf32
  • METTL11A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
tissue sample
0.69
transcription factor
0.61
transcription factor perturbation
0.54
histone modification site profile
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.07   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.07   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (37)
1 – 10 of 37
VAMP4
Tbio
Novelty: 0.02949854
p_int: 0.99999951
p_ni: 4.89e-7
p_wrong: 1e-9
Score: 0.38
Data Source: BioPlex,STRINGDB
DENR
Tbio
Novelty: 0.00653432
p_int: 0.999996889
p_ni: 0.00000311
p_wrong: 2e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
DRG1
Tbio
Novelty: 0.32024564
p_int: 0.999994988
p_ni: 0.000004994
p_wrong: 1.7e-8
Score: 0.537
Data Source: BioPlex,STRINGDB
TIRAP
Tbio
Novelty: 0.00600495
p_int: 0.999905836
p_ni: 0.00007261
p_wrong: 0.000021554
Score: 0.313
Data Source: BioPlex,STRINGDB
VCY
Tdark
p_int: 0.999657192
p_ni: 0.000184792
p_wrong: 0.000158016
Data Source: BioPlex
CCL5
Tchem
Novelty: 0.00032607
p_int: 0.990960426
p_ni: 0.002723153
p_wrong: 0.006316421
Score: 0.209
Data Source: BioPlex,STRINGDB
RCC1
Tbio
Novelty: 0.00260884
Score: 0.854
Data Source: STRINGDB
KLHL31
Tbio
Novelty: 0.10153296
Score: 0.81
Data Source: STRINGDB
RPL23A
Tbio
Novelty: 0.02951947
Score: 0.754
Data Source: STRINGDB
DDB2
Tbio
Novelty: 0.00648809
Score: 0.742
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.07

PubMed score by year
PubTator Score  13.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: