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Tbio
MECR
Enoyl-[acyl-carrier-protein] reductase, mitochondrial

Protein Summary
Description
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263702
  • ENSP00000263702
  • ENSG00000116353
  • ENST00000373791
  • ENSP00000362896

Symbol
  • NBRF1
  • ETR1
  • NRBF1
  • CGI-63
  • FASN2B
  • DYTOABG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
protein domain
0.73
cell type or tissue
0.69
histone modification site profile
0.65
microRNA
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.26   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.26   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
SNX30
Tdark
Novelty:  78
p_int:  0.999917257
p_ni:  0.000037877
p_wrong:  0.000044866
Data Source:  BioPlex
SNX4
Tbio
Novelty:  0.05441145
p_int:  0.99948063
p_ni:  0.000519261
p_wrong:  1.08e-7
Data Source:  BioPlex
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
p_int:  0.990613119
p_ni:  0.009384766
p_wrong:  0.000002115
Score:  0.316
Data Source:  BioPlex,STRINGDB
TAS2R41
Tchem
Family:  GPCR
Novelty:  0.56248837
p_int:  0.980293706
p_ni:  0.008610509
p_wrong:  0.011095785
Score:  0.332
Data Source:  BioPlex,STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.92102371
p_ni:  0.078976275
p_wrong:  1.6e-8
Score:  0.314
Data Source:  BioPlex,STRINGDB
HADHB
Tbio
Family:  Enzyme
Novelty:  0.00969194
Score:  0.93
Data Source:  STRINGDB
ACAA2
Tbio
Family:  Enzyme
Novelty:  0.01452373
Score:  0.929
Data Source:  STRINGDB
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
Score:  0.916
Data Source:  STRINGDB
HADHA
Tbio
Novelty:  0.00385746
Score:  0.914
Data Source:  STRINGDB
PPT1
Tbio
Family:  Enzyme
Novelty:  0.0028576
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (R-HSA-77346)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
62.1
hemoglobin measurement
2
1
2
59.9
diastolic blood pressure
1
1
1
50.6
high density lipoprotein cholesterol measurement
1
1
1
42.3
apolipoprotein A 1 measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
62.1
hemoglobin measurement
2
59.9
diastolic blood pressure
1
50.6
high density lipoprotein cholesterol measurement
1
42.3
apolipoprotein A 1 measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial trans-2-enoyl-CoA reductase
VGNC:10714
456690
Macaque
mitochondrial trans-2-enoyl-CoA reductase
717425
Mouse
MGI:1349441
26922
Rat
RGD:3208
29470
Dog
mitochondrial trans-2-enoyl-CoA reductase
VGNC:43116
478159
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial trans-2-enoyl-CoA reductase
Macaque
mitochondrial trans-2-enoyl-CoA reductase
Mouse
Rat
Dog
mitochondrial trans-2-enoyl-CoA reductase
Publication Statistics
PubMed Score 78.26
PubMed score by year
PubTator Score 11.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title