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Tbio
CEP250
Centrosome-associated protein CEP250

Protein Summary
Description
Probably plays an important role in centrosome cohesion during interphase. This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397527
  • ENSP00000380661
  • ENSG00000126001

Symbol
  • CEP2
  • CNAP1
  • CEP2
  • CNAP1
  • C-NAP1
  • CRDHL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cellular component
0.74
transcription factor binding site profile
0.64
transcription factor
0.63
cell line
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
23
31
99.5
appendicular lean mass
3
6
12
99.3
body height
8
7
12
99.2
BMI-adjusted waist-hip ratio
10
7
20
94.8
total cholesterol measurement
6
7
12
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
31
99.5
appendicular lean mass
12
99.3
body height
12
99.2
BMI-adjusted waist-hip ratio
20
94.8
total cholesterol measurement
12
90.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 250
VGNC:6076
458203
Macaque
centrosomal protein 250
705173
Mouse
MGI:108084
16328
Rat
RGD:1562262
311573
Dog
centrosomal protein 250
VGNC:39124
485851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 250
Macaque
centrosomal protein 250
Mouse
Rat
Dog
centrosomal protein 250
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BV73-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (160)
1 – 10 of 160
MRGBP
Tbio
Novelty:  0.09537142
p_int:  0.999999892
p_ni:  1.08e-7
Data Source:  BioPlex
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999999212
p_ni:  7.88e-7
Data Source:  BioPlex
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.999998544
p_ni:  0.000001456
Data Source:  BioPlex
NUP54
Tbio
Novelty:  0.08155008
p_int:  0.999955853
p_ni:  0.000044147
Score:  0.183
Data Source:  BioPlex,STRINGDB
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999796744
p_ni:  0.000203256
Data Source:  BioPlex
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.999757654
p_ni:  0.000242346
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.994929128
p_ni:  0.005070872
Data Source:  BioPlex
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.992501885
p_ni:  0.007498115
Data Source:  BioPlex
CEP170
Tbio
Novelty:  0.05342931
p_int:  0.963981106
p_ni:  0.036018894
Score:  0.601
Data Source:  BioPlex,STRINGDB
LZTFL1
Tbio
Novelty:  0.10578428
p_int:  0.951495929
p_ni:  0.048504071
Score:  0.196
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  12.02

PubMed score by year
PubTator Score  29.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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