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Tbio
ADI1
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Protein Summary
Description
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327435
  • ENSP00000333666
  • ENSG00000182551
  • ENST00000382093
  • ENSP00000371525

Symbol
  • MTCBP1
  • ARD
  • APL1
  • SIPL
  • mtnD
  • Fe-ARD
  • MTCBP1
  • Ni-ARD
  • HMFT1638
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
histone modification site profile
0.86
kinase perturbation
0.71
tissue
0.71
tissue sample
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.66   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.66   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
ENOPH1
Tbio
Family:  Enzyme
Novelty:  0.07679925
Score:  0.996
Data Source:  STRINGDB
APIP
Tbio
Family:  Enzyme
Novelty:  0.04661109
Score:  0.959
Data Source:  STRINGDB
MRI1
Tbio
Family:  Enzyme
Novelty:  0.01167103
Score:  0.944
Data Source:  STRINGDB
TAT
Tbio
Family:  Enzyme
Novelty:  0.00079176
Score:  0.921
Data Source:  STRINGDB
IL4I1
Tbio
Family:  Enzyme
Novelty:  0.00414355
Score:  0.908
Data Source:  STRINGDB
PGM3
Tbio
Family:  Enzyme
Novelty:  0.00515842
Score:  0.708
Data Source:  STRINGDB
MMP14
Tchem
Family:  Enzyme
Novelty:  0.00083836
Score:  0.688
Data Source:  STRINGDB
KLHDC3
Tdark
Novelty:  0.63840156
Score:  0.686
Data Source:  STRINGDB
DGCR2
Tbio
Novelty:  0.05838132
Score:  0.654
Data Source:  STRINGDB
SMS
Tchem
Family:  Enzyme
Novelty:  0.02447112
Score:  0.62
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Methionine salvage pathway
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Methionine salvage pathway
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
82.9
low density lipoprotein cholesterol measurement
4
4
4
78.2
high density lipoprotein cholesterol measurement
3
2
3
77.8
apolipoprotein A 1 measurement
2
2
2
75
triglyceride measurement
2
2
2
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
82.9
low density lipoprotein cholesterol measurement
4
78.2
high density lipoprotein cholesterol measurement
3
77.8
apolipoprotein A 1 measurement
2
75
triglyceride measurement
2
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acireductone dioxygenase 1
VGNC:9
743384
Macaque
acireductone dioxygenase 1
722050
Mouse
MGI:2144929
104923
Rat
RGD:727828
298934
Dog
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
100856577
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acireductone dioxygenase 1
Macaque
acireductone dioxygenase 1
Mouse
Rat
Dog
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Publication Statistics
PubMed Score 115.66
PubMed score by year
PubTator Score 181.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title