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Tbio
DUSP26
Dual specificity protein phosphatase 26

Protein Summary
Description
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256261
  • ENSP00000256261
  • ENSG00000133878
  • ENST00000523956
  • ENSP00000429176

Symbol
  • DUSP24
  • LDP4
  • MKP8
  • NATA1
  • SKRP3
  • LDP4
  • MKP8
  • NEAP
  • DSP-4
  • LDP-4
  • MKP-8
  • NATA1
  • SKRP3
  • DUSP24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.91
biological process
0.78
cell type or tissue
0.73
PubMedID
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.92   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.92   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
AK2
Tbio
Family:  Kinase
Novelty:  0.00581034
Score:  0.725
Data Source:  STRINGDB
ADRA1B
Tclin
Family:  GPCR
Novelty:  0.00381271
Score:  0.682
Data Source:  STRINGDB
ADRA2A
Tclin
Family:  GPCR
Novelty:  0.00273659
Score:  0.679
Data Source:  STRINGDB
ADRA2B
Tclin
Family:  GPCR
Novelty:  0.00633206
Score:  0.675
Data Source:  STRINGDB
ADRA2C
Tclin
Family:  GPCR
Novelty:  0.00661399
Score:  0.673
Data Source:  STRINGDB
DBH
Tchem
Family:  Enzyme
Novelty:  0.00074741
Score:  0.672
Data Source:  STRINGDB
ADRA1A
Tclin
Family:  GPCR
Novelty:  0.00379919
Score:  0.671
Data Source:  STRINGDB
ADRB1
Tclin
Family:  GPCR
Novelty:  0.00111668
Score:  0.67
Data Source:  STRINGDB
ADRA1D
Tclin
Family:  GPCR
Novelty:  0.00203304
Score:  0.67
Data Source:  STRINGDB
ADRB3
Tclin
Family:  GPCR
Novelty:  0.00128102
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
1
2
1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
1
2.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 26
VGNC:14566
464104
Macaque
dual specificity phosphatase 26
697134
Mouse
MGI:1914209
66959
Rat
RGD:1310090
306527
Dog
dual specificity phosphatase 26
VGNC:51798
608368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 26
Macaque
dual specificity phosphatase 26
Mouse
Rat
Dog
dual specificity phosphatase 26
Publication Statistics
PubMed Score 27.92
PubMed score by year
PubTator Score 93.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title