Tbio DUSP26 Dual specificity protein phosphatase 26

Protein Summary

Description

Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q9BV47
• D3DSV8
• Q9BTW0

Gene Name

• DUSP26

Ensembl ID

• ENST00000256261
• ENSP00000256261
• ENSG00000133878
• ENST00000523956
• ENSP00000429176

Symbol

• DUSP24
• LDP4
• MKP8
• NATA1
• SKRP3
• LDP4
• MKP8
• NEAP
• DSP-4
• LDP-4
• MKP-8
• NATA1
• SKRP3
• DUSP24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
gene perturbation	0.91
biological process	0.78
cell type or tissue	0.73
PubMedID	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.74   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.74   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0