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Tbio
VAMP8
Vesicle-associated membrane protein 8

Protein Summary
Description
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t-SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Plays also a role in regulated enzyme secretion in pancreatic acinar cells (By similarity). Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells (By similarity). Involved in the homotypic fusion of early and late endosomes (By similarity). This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated mem ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263864
  • ENSP00000263864
  • ENSG00000118640

Symbol
  • EDB
  • VAMP-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
interacting protein
0.98
biological process
0.93
virus perturbation
0.83
PubMedID
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
4
3
1
1.1
96.8
2
2
1
1.1
71.7
eosinophil count
3
1
3
66.4
1
1
1
48.9
1
1
1
48.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
1
1.1
96.8
1
1.1
71.7
eosinophil count
3
66.4
1
48.9
1
48.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 8
VGNC:417
459365
Macaque
vesicle associated membrane protein 8
695851
Mouse
MGI:1336882
22320
Rat
RGD:620421
83730
Dog
vesicle associated membrane protein 8
VGNC:48227
609784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 8
Macaque
vesicle associated membrane protein 8
Mouse
Rat
Dog
vesicle associated membrane protein 8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BV40-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Cargo recognition for clathrin-mediated endocytosis
Class I MHC mediated antigen processing & presentation
Clathrin-mediated endocytosis
Gene Ontology Terms (34)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (485)
1 – 10 of 485
STX12
Tbio
Novelty: 0.03836262
p_int: 0.999998397
p_ni: 0.000001477
p_wrong: 1.26e-7
Score: 0.99
Data Source: BioPlex,STRINGDB
SYPL1
Tbio
Novelty: 0.04187055
p_int: 0.999993692
p_ni: 0.000001971
p_wrong: 0.000004338
Score: 0.309
Data Source: BioPlex,STRINGDB
STX19
Tdark
Novelty: 0.99387951
p_int: 0.999987715
p_ni: 0.000012284
Score: 0.793
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.999961679
p_ni: 0.000038282
p_wrong: 3.9e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
STX18
Tbio
Novelty: 0.0259034
p_int: 0.999953799
p_ni: 0.00004619
p_wrong: 1.2e-8
Score: 0.894
Data Source: BioPlex,STRINGDB
STX7
Tbio
Novelty: 0.03109969
p_int: 0.999931579
p_ni: 0.000053136
p_wrong: 0.000015285
Score: 0.973
Data Source: BioPlex,STRINGDB
STX11
Tbio
Novelty: 0.01670743
p_int: 0.999928563
p_ni: 0.000071372
p_wrong: 6.4e-8
Score: 0.931
Data Source: BioPlex,STRINGDB
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999926489
p_ni: 0.000073481
p_wrong: 3e-8
Score: 0.15
Data Source: BioPlex,STRINGDB
STX3
Tbio
Novelty: 0.01055819
p_int: 0.999854106
p_ni: 0.000145847
p_wrong: 4.7e-8
Score: 0.971
Data Source: BioPlex,STRINGDB
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.999778563
p_ni: 0.000221432
p_wrong: 5e-9
Score: 0.911
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  97.00

PubMed score by year
PubTator Score  128.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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