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Tbio
WDR18
WD repeat-containing protein 18

Protein Summary
Description
Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (PubMed:21326211). This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585809
  • ENSP00000476117
  • ENSG00000065268

Symbol
  • Ipi3
  • R32184_1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
transcription factor binding site profile
0.89
histone modification site profile
0.88
protein domain
0.85
hub protein
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (320)
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.999934426
p_ni:  0.00006557
p_wrong:  4e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
TEX10
Tdark
Novelty:  0.12988812
p_int:  0.999843072
p_ni:  0.000156928
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SENP3
Tbio
Family:  Enzyme
Novelty:  0.00374663
p_int:  0.999500332
p_ni:  0.000499668
Score:  0.998
Data Source:  BioPlex,STRINGDB
PELP1
Tbio
Novelty:  0.00817675
p_int:  0.998994562
p_ni:  0.001005438
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
NOL9
Tdark
Family:  Enzyme
Novelty:  0.05830272
p_int:  0.804689588
p_ni:  0.195310412
Score:  0.998
Data Source:  BioPlex,STRINGDB
LAS1L
Tbio
Novelty:  0.15470637
Score:  0.998
Data Source:  STRINGDB
WDR12
Tbio
Novelty:  0.03409059
Score:  0.996
Data Source:  STRINGDB
UTP14A
Tbio
Novelty:  0.06076507
Score:  0.993
Data Source:  STRINGDB
WDR75
Tbio
Novelty:  0.09443914
Score:  0.993
Data Source:  STRINGDB
UTP4
Tbio
Novelty:  0.06989008
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
9
17
99.3
reticulocyte count
7
8
25
99.2
lymphocyte count
4
4
5
97.5
mean platelet volume
3
5
6
95.6
red blood cell distribution width
4
3
5
94.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
17
99.3
reticulocyte count
25
99.2
lymphocyte count
5
97.5
mean platelet volume
6
95.6
red blood cell distribution width
5
94.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 18
VGNC:2204
455536
Macaque
WD repeat domain 18
704547
Mouse
MGI:2158400
216156
Rat
RGD:1310646
314617
Dog
WD repeat domain 18
VGNC:48354
612368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 18
Macaque
WD repeat domain 18
Mouse
Rat
Dog
WD repeat domain 18
Publication Statistics
PubMed Score 26.62
PubMed score by year
PubTator Score 26.76
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title