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Tchem
ABHD6
Monoacylglycerol lipase ABHD6

Protein Summary
Description
Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:22969151). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. May also have a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295962
  • ENSP00000295962
  • ENSG00000163686
  • ENST00000478253
  • ENSP00000420315
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.85
transcription factor binding site profile
0.76
cellular component
0.75
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.73   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.73   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
orlistat
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
4.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 6
VGNC:53352
470830
Macaque
abhydrolase domain containing 6
702384
Mouse
MGI:1913332
66082
Rat
RGD:1359323
305795
Dog
abhydrolase domain containing 6
VGNC:37472
484712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
abhydrolase domain containing 6
Macaque
abhydrolase domain containing 6
Mouse
Rat
Dog
abhydrolase domain containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BV23-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Arachidonate production from DAG (R-HSA-426048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonate production from DAG
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Arachidonate production from DAG
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (71)
1 – 10 of 71
NCS1
Tbio
Novelty: 0.0051468
p_int: 0.999998747
p_ni: 0.000001253
Score: 0.228
Data Source: BioPlex,STRINGDB
C5AR2
Tbio
Family: GPCR
Novelty: 0.01193736
p_int: 0.999978033
p_ni: 0.000021963
p_wrong: 4e-9
Data Source: BioPlex
PCDHA3
Tdark
Novelty: 0.8622898
p_int: 0.999977377
p_ni: 0.000022619
p_wrong: 3e-9
Score: 0.161
Data Source: BioPlex,STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.99994319
p_ni: 0.000055909
p_wrong: 9.01e-7
Data Source: BioPlex
FSHR
Tclin
Family: GPCR
Novelty: 0.00123929
p_int: 0.925110704
p_ni: 0.000662992
p_wrong: 0.074226304
Score: 0.207
Data Source: BioPlex,STRINGDB
ABHD12
Tchem
Family: Enzyme
Novelty: 0.02587535
Score: 0.964
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.882
Data Source: STRINGDB
FAAH
Tchem
Family: Enzyme
Novelty: 0.00162361
Score: 0.845
Data Source: STRINGDB
NAPEPLD
Tbio
Family: Enzyme
Novelty: 0.00755191
Score: 0.834
Data Source: STRINGDB
DSE
Tbio
Family: Enzyme
Novelty: 0.02945465
Score: 0.759
Data Source: STRINGDB
Publication Statistics
PubMed Score  50.73

PubMed score by year
PubTator Score  19.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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