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Tbio
MRI1
Methylthioribose-1-phosphate isomerase

Protein Summary
Description
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000040663
  • ENSP00000040663
  • ENSG00000037757
  • ENST00000319545
  • ENSP00000314871

Symbol
  • MRDI
  • M1Pi
  • MRDI
  • MTNA
  • Ypr118w
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
kinase perturbation
0.66
transcription factor binding site profile
0.61
transcription factor perturbation
0.61
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Methionine salvage pathway
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Methionine salvage pathway
Sulfur amino acid metabolism
Protein-Protein Interactions (52)
1 – 10 of 52
APIP
Tbio
Family: Enzyme
Novelty: 0.04661109
Score: 0.986
Data Source: STRINGDB
MTAP
Tchem
Family: Enzyme
Novelty: 0.00485488
Score: 0.966
Data Source: STRINGDB
LRRC40
Tdark
Novelty: 2.43377466
Score: 0.945
Data Source: STRINGDB
ADI1
Tbio
Family: Enzyme
Novelty: 0.00908955
Score: 0.944
Data Source: STRINGDB
KCTD3
Tdark
Novelty: 0.33599775
Score: 0.942
Data Source: STRINGDB
ENOPH1
Tbio
Family: Enzyme
Novelty: 0.07679925
Score: 0.921
Data Source: STRINGDB
CYREN
Tbio
Novelty: 0.00278834
Score: 0.921
Data Source: STRINGDB
CDC23
Tbio
Novelty: 0.0168525
Score: 0.835
Data Source: STRINGDB
POLR1B
Tbio
Family: Enzyme
Novelty: 0.06955307
Score: 0.81
Data Source: STRINGDB
MCM6
Tbio
Novelty: 0.00675724
Score: 0.744
Data Source: STRINGDB
Publication Statistics
PubMed Score  75.77

PubMed score by year
PubTator Score  155.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer