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Tbio
MRI1
Methylthioribose-1-phosphate isomerase

Protein Summary
Description
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000040663
  • ENSP00000040663
  • ENSG00000037757
  • ENST00000319545
  • ENSP00000314871

Symbol
  • MRDI
  • M1Pi
  • MRDI
  • MTNA
  • Ypr118w
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
kinase perturbation
0.66
transcription factor binding site profile
0.61
transcription factor perturbation
0.61
disease
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
APIP
Tbio
Family:  Enzyme
Novelty:  0.04661109
Score:  0.986
Data Source:  STRINGDB
MTAP
Tchem
Family:  Enzyme
Novelty:  0.00485488
Score:  0.966
Data Source:  STRINGDB
LRRC40
Tdark
Novelty:  2.43377466
Score:  0.945
Data Source:  STRINGDB
ADI1
Tbio
Family:  Enzyme
Novelty:  0.00908955
Score:  0.944
Data Source:  STRINGDB
KCTD3
Tdark
Novelty:  0.33599775
Score:  0.942
Data Source:  STRINGDB
ENOPH1
Tbio
Family:  Enzyme
Novelty:  0.07679925
Score:  0.921
Data Source:  STRINGDB
CYREN
Tbio
Novelty:  0.00278834
Score:  0.921
Data Source:  STRINGDB
CDC23
Tbio
Novelty:  0.0168525
Score:  0.835
Data Source:  STRINGDB
POLR1B
Tbio
Family:  Enzyme
Novelty:  0.06955307
Score:  0.81
Data Source:  STRINGDB
MCM6
Tbio
Novelty:  0.00675724
Score:  0.744
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Methionine salvage pathway
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Methionine salvage pathway
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
3
4
88.6
leukocyte count
3
3
3
74.1
brain measurement
1
1
0
11.2
69.4
myeloid white cell count
1
1
1
67.8
lymphocyte percentage of leukocytes
1
1
1
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
88.6
leukocyte count
3
74.1
brain measurement
0
11.2
69.4
myeloid white cell count
1
67.8
lymphocyte percentage of leukocytes
1
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylthioribose-1-phosphate isomerase 1
VGNC:2414
747838
Macaque
methylthioribose-1-phosphate isomerase 1
718413
Mouse
MGI:1915123
67873
Rat
RGD:1307789
288912
Dog
methylthioribose-1-phosphate isomerase 1
VGNC:43365
484914
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylthioribose-1-phosphate isomerase 1
Macaque
methylthioribose-1-phosphate isomerase 1
Mouse
Rat
Dog
methylthioribose-1-phosphate isomerase 1
Publication Statistics
PubMed Score 115.77
PubMed score by year
PubTator Score 155.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title