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Tbio
TRAF4
TNF receptor-associated factor 4

Protein Classes
Protein Summary
Description
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262395
  • ENSP00000262395
  • ENSG00000076604

Symbol
  • CART1
  • MLN62
  • RNF83
  • CART1
  • MLN62
  • RNF83
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.95
kinase perturbation
0.91
molecular function
0.9
PubMedID
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.22   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.22   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
95.8
red blood cell distribution width
1
1
1
85.3
hemoglobin measurement
2
2
2
84.3
reticulocyte count
2
2
2
83
reticulocyte measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
95.8
red blood cell distribution width
1
85.3
hemoglobin measurement
2
84.3
reticulocyte count
2
83
reticulocyte measurement
1
58.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 4
VGNC:9737
454534
Macaque
TNF receptor associated factor 4
716364
Mouse
MGI:1202880
22032
Rat
RGD:1306708
303285
Dog
TNF receptor associated factor 4
VGNC:47768
100688511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 4
Macaque
TNF receptor associated factor 4
Mouse
Rat
Dog
TNF receptor associated factor 4
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BUZ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (44)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Small cell lung cancer
KEGG
IL-17 signaling pathway
KEGG
Pathways in cancer
Name
Explore in Pharos
Explore in Source
Small cell lung cancer
IL-17 signaling pathway
Pathways in cancer
Gene Ontology Terms (24)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (85)
1 – 10 of 85
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.999999481
p_ni:  5.18e-7
Score:  0.36
Data Source:  BioPlex,STRINGDB
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.999994022
p_ni:  0.000005966
p_wrong:  1.2e-8
Data Source:  BioPlex
ARNT2
Tbio
Family:  TF
Novelty:  0.01485424
p_int:  0.999993823
p_ni:  0.000006174
p_wrong:  3e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
CATSPER4
Tchem
Family:  IC
Novelty:  0.4554917
p_int:  0.99994854
p_ni:  0.000050961
p_wrong:  4.99e-7
Score:  0.53
Data Source:  BioPlex,STRINGDB
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.999149666
p_ni:  0.000061833
p_wrong:  0.000788502
Score:  0.185
Data Source:  BioPlex,STRINGDB
CDC123
Tbio
Novelty:  0.05599841
p_int:  0.759282467
p_ni:  0.000131979
p_wrong:  0.240585554
Data Source:  BioPlex
IRAK1
Tchem
Family:  Kinase
Novelty:  0.00170873
Score:  0.836
Data Source:  STRINGDB
CD40
Tchem
Novelty:  0.0002836
Score:  0.826
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.799
Data Source:  STRINGDB
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
Score:  0.779
Data Source:  STRINGDB
Publication Statistics
PubMed Score  86.22

PubMed score by year
PubTator Score  49.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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