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Tbio
CHAC1
Glutathione-specific gamma-glutamylcyclotransferase 1

Protein Summary
Description
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000444189
  • ENSP00000395466
  • ENSG00000128965
  • ENST00000446533
  • ENSP00000398105

Symbol
  • BOTCH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
small molecule perturbation
0.97
transcription factor perturbation
0.88
histone modification site profile
0.83
PubMedID
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.36   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.36   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
ATF4
Tbio
Family:  TF
Novelty:  0.00253408
Score:  0.74
Data Source:  STRINGDB
TRIB3
Tbio
Family:  Kinase
Novelty:  0.00827893
Score:  0.689
Data Source:  STRINGDB
ATF3
Tbio
Family:  TF
Novelty:  0.00164508
Score:  0.594
Data Source:  STRINGDB
ASNS
Tchem
Family:  Enzyme
Novelty:  0.00337445
Score:  0.59
Data Source:  STRINGDB
NRN1L
Tdark
Novelty:  0.56477474
Score:  0.579
Data Source:  STRINGDB
ABHD17B
Tbio
Family:  Enzyme
Novelty:  0.64360453
Score:  0.579
Data Source:  STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
Score:  0.574
Data Source:  STRINGDB
P0DPQ6
Tbio
Novelty:  0.00116135
Score:  0.568
Data Source:  STRINGDB
P35638
Tchem
Family:  TF
Novelty:  0.00116135
Score:  0.568
Data Source:  STRINGDB
LYAR
Tbio
Novelty:  0.04324088
Score:  0.561
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Glutathione synthesis and recycling
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Glutathione synthesis and recycling
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
2
2
72.3
intelligence
3
1
1
5.7
45.2
age at menopause
1
1
1
44.2
cognitive function measurement
3
1
3
40.7
self reported educational attainment
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
72.3
intelligence
1
5.7
45.2
age at menopause
1
44.2
cognitive function measurement
3
40.7
self reported educational attainment
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ChaC glutathione specific gamma-glutamylcyclotransferase 1
705007
Mouse
MGI:1916315
69065
Rat
RGD:1307153
362196
Dog
ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680]
Horse
ChaC glutathione specific gamma-glutamylcyclotransferase 1
VGNC:51480
100071253
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ChaC glutathione specific gamma-glutamylcyclotransferase 1
Mouse
Rat
Dog
ChaC glutathione specific gamma-glutamylcyclotransferase 1 [Source:HGNC Symbol;Acc:HGNC:28680]
Horse
ChaC glutathione specific gamma-glutamylcyclotransferase 1
Publication Statistics
PubMed Score 42.36
PubMed score by year
PubTator Score 13.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title