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Tbio
BDH2
3-hydroxybutyrate dehydrogenase type 2

Protein Summary
Description
Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296424
  • ENSP00000296424
  • ENSG00000164039

Symbol
  • DHRS6
  • SDR15C1
  • DHRS6
  • EFA6R
  • SDR15C1
  • UCPA-OR
  • UNQ6308
  • PRO20933
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
cell type or tissue
0.78
transcription factor perturbation
0.68
virus perturbation
0.64
microRNA
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.84   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.84   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
79.2
3
1
0
1.3
72.2
glomerular filtration rate
1
2
2
68.1
1
1
0
1.1
65.5
1
1
0
1.1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
79.2
0
1.3
72.2
glomerular filtration rate
2
68.1
0
1.1
65.5
0
1.1
54.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
3-hydroxybutyrate dehydrogenase 2
711108
Mouse
MGI:1917022
69772
Rat
RGD:1309898
295458
Dog
3-hydroxybutyrate dehydrogenase 2
VGNC:38423
100855513
Horse
3-hydroxybutyrate dehydrogenase 2
VGNC:15805
100068172
Species
Name
OMA
EggNOG
Inparanoid
Macaque
3-hydroxybutyrate dehydrogenase 2
Mouse
Rat
Dog
3-hydroxybutyrate dehydrogenase 2
Horse
3-hydroxybutyrate dehydrogenase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BUT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Ketone body metabolism (R-HSA-74182)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Ketone Bodies
Name
Explore in Pharos
Explore in Source
Ketone body metabolism
Metabolism
Metabolism of lipids
Synthesis of Ketone Bodies
Protein-Protein Interactions (40)
1 – 10 of 40
CDCA4
Tbio
Novelty:  0.04549061
p_int:  0.990494111
p_ni:  0.009505889
Score:  0.187
Data Source:  BioPlex,STRINGDB
RAB27B
Tbio
Family:  Enzyme
Novelty:  0.01530218
p_int:  0.989433105
p_ni:  0.010566895
Score:  0.189
Data Source:  BioPlex,STRINGDB
AVP
Tbio
Novelty:  0.00016475
p_int:  0.989167856
p_ni:  0.010832144
Score:  0.19
Data Source:  BioPlex,STRINGDB
EID1
Tbio
Novelty:  0.02414732
p_int:  0.987215012
p_ni:  0.012783009
p_wrong:  0.000001979
Score:  0.188
Data Source:  BioPlex,STRINGDB
CITED1
Tbio
Novelty:  0.01956689
p_int:  0.984940144
p_ni:  0.015059855
Data Source:  BioPlex
TEX13A
Tdark
Novelty:  1.13928013
p_int:  0.956970747
p_ni:  0.042987945
p_wrong:  0.000041308
Score:  0.205
Data Source:  BioPlex,STRINGDB
TRIB2
Tbio
Family:  Kinase
Novelty:  0.02240668
p_int:  0.891539714
p_ni:  0.108460274
p_wrong:  1.3e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
GOLGA7
Tbio
Novelty:  0.17108842
p_int:  0.883987213
p_ni:  0.116012787
Data Source:  BioPlex
CFAP36
Tdark
Novelty:  0.42842118
p_int:  0.866010706
p_ni:  0.133989282
p_wrong:  1.2e-8
Score:  0.209
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.772170958
p_ni:  0.227290528
p_wrong:  0.000538514
Data Source:  BioPlex
Publication Statistics
PubMed Score  29.84

PubMed score by year
PubTator Score  8.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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