Tbio BDH2 3-hydroxybutyrate dehydrogenase type 2

Protein Summary

Description

Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372).

Uniprot Accession IDs

• Q9BUT1
• A8K295
• B4DUF6
• Q503A0
• Q6IA46
• Q6UWD3
• Q9H8S8
• Q9NRX8

Gene Name

• BDH2

Ensembl ID

• ENST00000296424
• ENSP00000296424
• ENSG00000164039

Symbol

• DHRS6
• SDR15C1
• DHRS6
• EFA6R
• SDR15C1
• UCPA-OR
• UNQ6308
• PRO20933

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.79
cell type or tissue	0.78
transcription factor perturbation	0.68
virus perturbation	0.64
microRNA	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.17   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.17   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0