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Tbio
WRAP53
Telomerase Cajal body protein 1

Protein Summary
Description
RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies (PubMed:29804836, PubMed:29695869). Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC) (PubMed:19285445, PubMed:20351177, PubMed:29804836, PubMed:29695869). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (PubMed:19179534, PubMed:20351177, PubMed:26170453, PubMed:29695869). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex (PubMed:27525486, PubMed:29804836). Acts by specifically binding the CAB box of the TERC RNA and controlling the folding of the CR4/CR5 region of the TERC RNA, a critical step for telomerase activity (PubMed:29804836). In addition, also controls telomerase holoenzyme complex localization to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316024
  • ENSP00000324203
  • ENSG00000141499
  • ENST00000396463
  • ENSP00000379727
  • ENST00000431639
  • ENSP00000397219
  • ENST00000457584
  • ENSP00000411061

Symbol
  • TCAB1
  • WDR79
  • DKCB3
  • TCAB1
  • WDR79
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
transcription factor
0.9
PubMedID
0.57
tissue
0.57
cell type or tissue
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
42.6
testosterone measurement
1
1
1
41.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
42.6
testosterone measurement
1
41.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat containing antisense to TP53
VGNC:10148
455213
Macaque
WD repeat containing antisense to TP53
716125
Mouse
MGI:2384933
216853
Rat
RGD:1359624
287432
Dog
WD repeat containing antisense to TP53
VGNC:48432
607892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat containing antisense to TP53
Macaque
WD repeat containing antisense to TP53
Mouse
Rat
Dog
WD repeat containing antisense to TP53
Pathways (9)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Cell Cycle
Reactome
Chaperonin-mediated protein folding
Reactome
Chromosome Maintenance
Reactome
Extension of Telomeres
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
Cell Cycle
Chaperonin-mediated protein folding
Chromosome Maintenance
Extension of Telomeres
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (115)
1 – 10 of 115
MEF2D
Tbio
Family: TF
Novelty: 0.00732653
p_int: 0.99999902
p_ni: 9.73e-7
p_wrong: 8e-9
Data Source: BioPlex
ATXN2
Tbio
Novelty: 0.00373116
p_int: 0.999145149
p_ni: 0.000854851
Data Source: BioPlex
DKC1
Tbio
Novelty: 0.00352181
p_int: 0.983813546
p_ni: 0.016186453
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
HELZ
Tbio
Family: Enzyme
Novelty: 0.08786982
p_int: 0.979143703
p_ni: 0.020856297
Data Source: BioPlex
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.970482209
p_ni: 0.029517791
Score: 0.938
Data Source: BioPlex,STRINGDB
NOP10
Tbio
Novelty: 0.0188462
p_int: 0.95210417
p_ni: 0.0477793
p_wrong: 0.000116529
Score: 0.961
Data Source: BioPlex,STRINGDB
TCP1
Tbio
Novelty: 0.00395241
p_int: 0.937569202
p_ni: 0.062430798
Score: 0.938
Data Source: BioPlex,STRINGDB
IQCN
Tdark
Novelty: 2.74045479
p_int: 0.93734789
p_ni: 0.06265211
Score: 0.401
Data Source: BioPlex,STRINGDB
ERF
Tbio
Family: TF
Novelty: 0.00182385
p_int: 0.929141228
p_ni: 0.070792022
p_wrong: 0.000066749
Data Source: BioPlex
FAM43A
Tdark
Novelty: 1.17401589
p_int: 0.916384228
p_ni: 0.083615772
Score: 0.243
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.61

PubMed score by year
PubTator Score  42.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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