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Tbio
DDX23
Probable ATP-dependent RNA helicase DDX23

Protein Summary
Description
Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308025
  • ENSP00000310723
  • ENSG00000174243
  • ENST00000547135
  • ENSP00000446770

Symbol
  • prp28
  • PRPF28
  • U5-100K
  • SNRNP100
  • U5-100KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.96
transcription factor binding site profile
0.91
hub protein
0.9
histone modification site profile
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.97   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.97   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (270)
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999988657
p_ni:  0.000011343
Score:  0.995
Data Source:  BioPlex,STRINGDB
EAPP
Tbio
Novelty:  0.06519266
p_int:  0.999878496
p_ni:  0.000121504
Score:  0.735
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999688629
p_ni:  0.000311371
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.999320314
p_ni:  0.000679686
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.998812921
p_ni:  0.001187079
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.997652907
p_ni:  0.002347093
Data Source:  BioPlex
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.996925317
p_ni:  0.003074683
Score:  0.998
Data Source:  BioPlex,STRINGDB
PRPF6
Tbio
Novelty:  0.02818008
p_int:  0.9967582
p_ni:  0.0032418
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.996701713
p_ni:  0.003298287
Score:  0.99
Data Source:  BioPlex,STRINGDB
IK
Tbio
Novelty:  0.01510642
p_int:  0.996547428
p_ni:  0.003452572
Score:  0.263
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
1
1
2
49.5
leukocyte count
1
1
1
46.5
calcium measurement
1
1
1
40.7
heel bone mineral density
1
1
1
33.1
testosterone measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
2
49.5
leukocyte count
1
46.5
calcium measurement
1
40.7
heel bone mineral density
1
33.1
testosterone measurement
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 23
VGNC:12924
451868
Macaque
DEAD-box helicase 23
708185
Mouse
MGI:1921601
74351
Rat
RGD:1308685
300208
Dog
DEAD-box helicase 23
VGNC:39850
477624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 23
Macaque
DEAD-box helicase 23
Mouse
Rat
Dog
DEAD-box helicase 23
Publication Statistics
PubMed Score 30.97
PubMed score by year
PubTator Score 8.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title