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Tbio
HTATIP2
Oxidoreductase HTATIP2

Protein Summary
Description
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419348
  • ENSP00000392985
  • ENSG00000109854
  • ENST00000421577
  • ENSP00000397752
  • ENST00000443524
  • ENSP00000387876
  • ENST00000451739
  • ENSP00000394259
  • ENST00000530266
  • ENSP00000436548
  • ENST00000532081
  • ENSP00000432107
  • ENST00000532505
  • ENSP00000432338

Symbol
  • CC3
  • TIP30
  • CC3
  • TIP30
  • SDR44U1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
virus perturbation
0.96
disease perturbation
0.93
kinase perturbation
0.88
cell type or tissue
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.23   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.23   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (61)
1 – 10 of 61
NCOA5
Tbio
Novelty:  0.09053523
p_int:  0.999820956
p_ni:  0.000179044
Score:  0.561
Data Source:  BioPlex,STRINGDB
AMOTL2
Tbio
Novelty:  0.04258164
p_int:  0.999819993
p_ni:  0.000179956
p_wrong:  5.1e-8
Score:  0.54
Data Source:  BioPlex,STRINGDB
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.969856393
p_ni:  0.019196399
p_wrong:  0.010947208
Data Source:  BioPlex
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
p_int:  0.842137299
p_ni:  0.157862529
p_wrong:  1.72e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CAVIN2
Tbio
Novelty:  0.00979388
Score:  0.8
Data Source:  STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
Score:  0.757
Data Source:  STRINGDB
APBB1
Tbio
Novelty:  0.00630564
Score:  0.693
Data Source:  STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
Score:  0.68
Data Source:  STRINGDB
HTATSF1
Tbio
Novelty:  0.04778721
Score:  0.672
Data Source:  STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
Score:  0.67
Data Source:  STRINGDB
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to alcohol
1
1
1
38.2
fractional shortening
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to alcohol
1
38.2
fractional shortening
1
0.3
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HIV-1 Tat interactive protein 2
VGNC:6748
451077
Mouse
MGI:1859271
53415
Rat
RGD:1309941
292935
Dog
HIV-1 Tat interactive protein 2
VGNC:41821
476886
Horse
HIV-1 Tat interactive protein 2
VGNC:18899
100057340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HIV-1 Tat interactive protein 2
Mouse
Rat
Dog
HIV-1 Tat interactive protein 2
Horse
HIV-1 Tat interactive protein 2
Publication Statistics
PubMed Score 70.23
PubMed score by year
PubTator Score 51.81
PubTator score by year