Tbio HTATIP2 Oxidoreductase HTATIP2

Protein Summary

Description

Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Uniprot Accession IDs

• Q9BUP3
• A8K7S7
• D3DQY8
• O15383
• O60520
• O95345
• Q53GC1
• Q53GG2
• Q6IBI3

Gene Name

• HTATIP2

Ensembl ID

• ENST00000419348
• ENSP00000392985
• ENSG00000109854
• ENST00000421577
• ENSP00000397752
• ENST00000443524
• ENSP00000387876
• ENST00000451739
• ENSP00000394259
• ENST00000530266
• ENSP00000436548
• ENST00000532081
• ENSP00000432107
• ENST00000532505
• ENSP00000432338

Symbol

• CC3
• TIP30
• CC3
• TIP30
• SDR44U1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
virus perturbation	0.96
disease perturbation	0.93
kinase perturbation	0.88
cell type or tissue	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.54   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.54   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0