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Tbio
DERL1
Derlin-1

Protein Classes
Protein Summary
Description
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259512
  • ENSP00000259512
  • ENSG00000136986
  • ENST00000405944
  • ENSP00000384289

Symbol
  • DER1
  • DER1
  • DER-1
  • derlin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
disease perturbation
0.96
kinase perturbation
0.93
protein complex
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
82.4
mean corpuscular volume
1
1
1
62.8
reticulocyte count
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
82.4
mean corpuscular volume
1
62.8
reticulocyte count
1
42.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
derlin 1
VGNC:892
464364
Macaque
derlin 1
703803
Mouse
MGI:1915069
67819
Rat
RGD:1311835
362912
Dog
derlin 1
VGNC:39902
475086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
derlin 1
Macaque
derlin 1
Mouse
Rat
Dog
derlin 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BUN8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Asparagine N-linked glycosylation
Reactome
Defective CFTR causes cystic fibrosis
Reactome
Disease
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Asparagine N-linked glycosylation
Defective CFTR causes cystic fibrosis
Disease
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (159)
1 – 10 of 159
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
Score:  0.999
Data Source:  STRINGDB
DERL2
Tbio
Novelty:  0.02479307
Score:  0.994
Data Source:  STRINGDB
SELENOS
Tbio
Novelty:  0.01108715
Score:  0.994
Data Source:  STRINGDB
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
Score:  0.993
Data Source:  STRINGDB
SEL1L
Tbio
Novelty:  0.01198173
Score:  0.99
Data Source:  STRINGDB
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
Score:  0.987
Data Source:  STRINGDB
RNF5
Tbio
Family:  Enzyme
Novelty:  0.03015609
Score:  0.982
Data Source:  STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.976
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.969
Data Source:  STRINGDB
ERLEC1
Tbio
Novelty:  0.01243855
Score:  0.965
Data Source:  STRINGDB
Publication Statistics
PubMed Score  73.00

PubMed score by year
PubTator Score  79.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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