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Tbio
G6PC3
Glucose-6-phosphatase 3

Protein Summary
Description
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function. This gene encodes the catalytic subunit of glucose-6-phosphatase (G6Pase). G6Pase is located in the endoplasmic reticulum (ER) and catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways. Mutations in this gene result in autosomal recessive severe congenital neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269097
  • ENSP00000269097
  • ENSG00000141349

Symbol
  • UGRP
  • SCN4
  • UGRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.68
transcription factor binding site profile
0.66
phenotype
0.61
tissue sample
0.59
transcription factor
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.98   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.98   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
GCK
Tchem
Family:  Kinase
Novelty:  0.00112778
Score:  0.932
Data Source:  STRINGDB
LCT
Tbio
Family:  Enzyme
Novelty:  0.0019382
Score:  0.916
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.916
Data Source:  STRINGDB
GALM
Tbio
Family:  Enzyme
Novelty:  0.01067063
Score:  0.915
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.91
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.901
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.9
Data Source:  STRINGDB
PGM2
Tbio
Family:  Enzyme
Novelty:  0.00922421
Score:  0.9
Data Source:  STRINGDB
HAX1
Tbio
Novelty:  0.00749205
Score:  0.898
Data Source:  STRINGDB
HK3
Tbio
Family:  Kinase
Novelty:  0.0151241
Score:  0.855
Data Source:  STRINGDB
Pathways (152)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Gluconeogenesis
Glucose metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
96.8
femoral neck bone mineral density
1
1
1
76.3
sex hormone-binding globulin measurement
4
2
4
55.2
high density lipoprotein cholesterol measurement
1
1
1
54.4
urate measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
96.8
femoral neck bone mineral density
1
76.3
sex hormone-binding globulin measurement
4
55.2
high density lipoprotein cholesterol measurement
1
54.4
urate measurement
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucose-6-phosphatase catalytic subunit 3
VGNC:9289
454720
Mouse
MGI:1915651
68401
Rat
RGD:727875
303565
Dog
glucose-6-phosphatase catalytic subunit 3
VGNC:41042
490942
Horse
glucose-6-phosphatase catalytic subunit 3
VGNC:18182
100064862
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucose-6-phosphatase catalytic subunit 3
Mouse
Rat
Dog
glucose-6-phosphatase catalytic subunit 3
Horse
glucose-6-phosphatase catalytic subunit 3
Publication Statistics
PubMed Score 64.98
PubMed score by year
PubTator Score 85.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title