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Tbio
PDCD10
Programmed cell death protein 10

Protein Summary
Description
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity (PubMed:27807006). Important for cell migration, and for normal structure and assembly of the Golgi complex (PubMed:27807006). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malf ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392750
  • ENSP00000376506
  • ENSG00000114209
  • ENST00000461494
  • ENSP00000420021
  • ENST00000470131
  • ENSP00000417202
  • ENST00000473645
  • ENSP00000418317
  • ENST00000497056
  • ENSP00000420553

Symbol
  • CCM3
  • TFAR15
  • CCM3
  • TFAR15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
virus perturbation
0.97
interacting protein
0.96
protein complex
0.95
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.97   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.97   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
95.1
platelet count
1
1
1
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95.1
platelet count
1
68.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 10
VGNC:2502
743651
Macaque
programmed cell death 10
699597
Mouse
MGI:1928396
56426
Rat
RGD:1359329
494345
Dog
programmed cell death 10
VGNC:53465
488145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
programmed cell death 10
Macaque
programmed cell death 10
Mouse
Rat
Dog
programmed cell death 10
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BUL8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Validated targets of C-MYC transcriptional activation
Name
Explore in Pharos
Explore in Source
Validated targets of C-MYC transcriptional activation
Protein-Protein Interactions (85)
1 – 10 of 85
STK25
Tchem
Family:  Kinase
Novelty:  0.03229688
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
STK24
Tchem
Family:  Kinase
Novelty:  0.00457236
p_int:  1
Score:  0.987
Data Source:  BioPlex,STRINGDB
STK26
Tchem
Family:  Kinase
Novelty:  0.03633178
p_int:  0.999999996
p_ni:  4e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.999999983
p_ni:  1.7e-8
Score:  0.369
Data Source:  BioPlex,STRINGDB
C4orf19
Tdark
Novelty:  2.1863624
p_int:  0.999997599
p_ni:  0.000002401
Score:  0.86
Data Source:  BioPlex,STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
p_int:  0.999816221
p_ni:  0.000183779
Score:  0.936
Data Source:  BioPlex,STRINGDB
BMP7
Tbio
Novelty:  0.00049424
p_int:  0.999564843
p_ni:  0.000435157
Score:  0.189
Data Source:  BioPlex,STRINGDB
STRIP2
Tbio
Novelty:  0.19321125
p_int:  0.998711816
p_ni:  0.001276093
p_wrong:  0.000012091
Score:  0.567
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.997432819
p_ni:  0.002567181
Data Source:  BioPlex
FGFR1OP2
Tbio
Novelty:  0.1082136
p_int:  0.996652723
p_ni:  0.002935504
p_wrong:  0.000411773
Score:  0.926
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  171.97

PubMed score by year
PubTator Score  101.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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