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Tdark
CHCHD7
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303759
  • ENSP00000306425
  • ENSG00000170791
  • ENST00000355315
  • ENSP00000347469
  • ENST00000518801
  • ENSP00000428274
  • ENST00000519367
  • ENSP00000428095
  • ENST00000521524
  • ENSP00000430458
  • ENST00000521831
  • ENSP00000429635
  • ENST00000523975
  • ENSP00000428917

Symbol
  • COX23
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.98
disease perturbation
0.97
histone modification site profile
0.8
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.04   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.04   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
S100A6
Tbio
Novelty:  0.00176164
p_int:  0.988384885
p_ni:  0.011615114
p_wrong:  1e-9
Score:  0.685
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
Score:  0.963
Data Source:  STRINGDB
GFER
Tchem
Family:  Enzyme
Novelty:  0.00338563
Score:  0.944
Data Source:  STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.935
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.922
Data Source:  STRINGDB
CYC1
Tchem
Novelty:  0.01369865
Score:  0.92
Data Source:  STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
Score:  0.919
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.909
Data Source:  STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
Score:  0.907
Data Source:  STRINGDB
ATP5MC1
Tbio
Family:  Enzyme
Novelty:  0.03538978
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
6
9
10
98.1
appendicular lean mass
3
4
7
97.7
BMI-adjusted hip circumference
3
11
11
92.6
platelet crit
1
1
1
64
birth weight
2
2
2
62
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
10
98.1
appendicular lean mass
7
97.7
BMI-adjusted hip circumference
11
92.6
platelet crit
1
64
birth weight
2
62
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain containing 7
VGNC:7741
745596
Mouse
MGI:1913683
66433
Rat
RGD:1592689
684258
Dog
coiled-coil-helix-coiled-coil-helix domain containing 7
VGNC:39198
609282
Horse
coiled-coil-helix-coiled-coil-helix domain containing 7
VGNC:16481
100629901
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coiled-coil-helix-coiled-coil-helix domain containing 7
Mouse
Rat
Dog
coiled-coil-helix-coiled-coil-helix domain containing 7
Horse
coiled-coil-helix-coiled-coil-helix domain containing 7
Publication Statistics
PubMed Score 27.04
PubMed score by year
PubTator Score 5.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title